2型糖尿病患者夜间低血糖预警及干预.pdfVIP

660 ·临床研究· 2型糖尿病患者夜间低血糖预警及干预 王砚 关守萍牛奔 薛元明 【摘要】 目的评估2型糖尿病患者日常临床环境中发生夜间低血糖的危险因素，寻求预测夜间低 血糖发生的量化指标。探讨临床干预危险因素后的效应。方法对血糖控制达标的2型糖尿病患者1147 h血糖两组间夜间低血糖 例。应用动态血糖监测系统(CGMS)监测全天血糖(BG)变化，比较不同晚餐后3 发生率。结果 低血糖、无症状低血糖及夜间低血糖发生率分别为37．23％、22．75％和18．31％。 22：00～2：00是夜间低血糖的高发时间段(RR=1．72，疋2=31．667，P0．01)。干预组夜间低血糖发生率 较对照组明显降低(9．67％对16．76％，x2=8．79，P0．01)。结论2型糖尿病患者夜间低血糖发生率高， 22：00～2：00是夜间低血糖的高发时间段，适当干预可以降低夜间低血糖的发生。 【关键词】低血糖症；动态血糖监测系统；糖尿病，2型 andinterventionofnocturnal in with 2diabetesmellitusWANG Earlywarning hypoglycemiapatientstype and Yah，GUAN Ben，XUE ofEndocrineMetabolism，First Shouting，NIUYuan—ming．Department People!SHospital Yunnan 650032，China of Province，Kunming author：XUE Correspondence Yuan—ming，Email：xym@public．km．yn．cn To riskfactorsofnocturnal in with 2diabetes 【Abstract】Objectiveinvestigate hypoglycemiapatientstype seek indicatorsfor toevaluatetheeffectsofintervention．Methods24．h mellitus．to quantitative earlywarning．and blood of1 147 with 2diabetesmellituswithwell—controlled weredetermined glucose patientstype hyperglycemia by continuous of were between with glucosemonitoringsystem(CGMS)．Incidenceshypoglycemiacompared groups different3h blood levelsafter Theratesof postprandialglucose supper．Results hypoglycemia，asymptomatic nocturnal were 18．31％．Nocturnal hypoglycemiarespectively37．23％，22．75％，and hypoglycemia，and setinmost hypoglycemiafrequentlyby22：00-2：00(RR=1．72，z==31．667，尸0．01)．Thehypoglycemia incidencewasreducedininterventionthanthatincontrol 1 6．76％，疋2=8．79，P group