恩度肝动脉灌注联合介入化疗栓塞治疗中晚期肝癌的疗效及安全性.docVIP

精品论文 参考文献 恩度肝动脉灌注联合介入化疗栓塞治疗中晚期肝癌的疗效及安全性 湖北民族学院附属民大医院 湖北恩施 445000 【摘 要】目的：探究在中晚期肝癌的治疗当中应用恩度肝动脉灌注联合介入化疗栓塞治疗的临床疗效。方法：选择2011年4月-2016年4月之间在我院就诊的中晚期肝癌患者83例，应用随机数字表法对所选患者进行分组，实验组42例，应用恩度肝动脉灌注联合介入化疗栓塞治疗，对照组41例，应用肝动脉化疗栓塞术进行治疗，三次治疗后，比较两组患者的临床治疗效果以及不良反应发生情况。结果：实验组患者治疗总有效率为71.43%，对照组仅为53.66%，两组相比差异有统计学意义（plt;0.05）。实验组有23.80%的患者出现了不良反应，对照组有21.85%的患者出现了不良反应，两组无统计学差异.结论：在中晚期肝癌的治疗当中，恩度肝动脉灌注联合介入化疗栓塞治疗的临床疗效好且安全性较高，适合在临床推广。 【关键词】中晚期肝癌；恩度；肝动脉化疗栓塞 Abstract：objective：To plore the application in the middle-late stage of the treatment of liver cancer，degree of the hepatic artery perfusion combined the clinical curative effect of interventional chemotherapy embolization. Methods：Between April 2011-April 2016 in our hospital in the middle-late 83 cases of liver cancer patients，patients with random number table method was applied to the selected group，experimental group 42 cases，the application of combined intervention en degrees of hepatic arterial infusion chemotherapy embolization，41 cases in the control group，treatment，application of the hepatic artery chemoembolization three times after treatment，compared two groups of patients with curative effect of solid tumors，AFP turn rate and adverse reactions occur. Results：The experimental group patients treatment the total effective rate was 71.43%，the control group was only 53.66%，compared two groups was statistically significant difference （p lt; 0.05）. The experimental group had 23.80% of the patients appeared adverse reactions，the control group，21.85% of patients appeared adverse reactions，no statistical differences in the two groups. Conclusion：in the middle-late stage of the treatment of liver cancer，degree of the hepatic artery perfusion combined interventional chemotherapy embolism good clinical efficacy and safety of high，suitable for clinical promotion. Key words：terminal-stage liver cancer；Grace；Hepatic artery embolism chemotherapy 目前临床上治疗肝癌的首选方法就是肝动脉化疗栓塞治疗[1]。但是，已经有研究证实，经肝动脉化疗栓塞治疗后，肿瘤会呈现缺血和缺氧的状态，导致血管内皮生长因子增多，进而加重肿瘤的转移以