替格瑞洛与氯吡格雷对急性冠状动脉(冠脉)综合征(ACS)患者的临床疗效观察.docVIP

精品论文 参考文献 替格瑞洛与氯吡格雷对急性冠状动脉(冠脉)综合征(ACS)患者的临床疗效观察 努尔布维?吐尔孙 姚晓光 李南方（通讯作者） 　　（新疆维吾尔自治区人民医院高血压中心 新疆乌鲁木齐 830001） 　　【摘要】目的：研究替格瑞洛与氯吡格雷治疗ACS的临床疗效。方法：将我院收治的70例ACS患者随机分为观察组合对照组各35例，对照组患者给予阿司匹林联合氯吡格雷口服抗血小板治疗，观察组患者给予阿司匹林联合替格瑞洛口服抗血小板治疗。两组患者均持续治疗1个月。比较两组患者治疗前后PAR及hs-CRP水平变化并记录两组患者随访期间终点事件及不良反应发生情况。结果：两组患者治疗前PAR及hs-CRP水平无明显差异（Pgt;0.05），治疗后1d、7d、28d观察组患者PAR及hs-CRP水平均显著低于对照组（Plt;0.01）；观察组患者随访期间终点事件发生率5.71%显著低于对照组患者22.86%（Plt;0.05）；两组患者不良反应发生率无显著差异（Pgt;0.05）。结论：替格瑞洛用于治疗ACS具有更好的抗血小板聚集和炎症反应作用，能显著避免患者终点事件的发生，值得临床推广应用。 　　【关键词】替格瑞洛；氯吡格雷；急性冠脉综合症；临床效果 　　【中图分类号】R37 【文献标识码】A 【文章编号】1007-8231（2015）22-0041-02 　　Clinical Effect of Ticagrelor and Clopidogrel in Treating ACS Patients Nuerbuwei Tuersun, Yao xiaoguang,Li Nanfang 　　Hypertention Center,people`s Hospital of Xinjiang uygur Autonomous Region 830001,China 　　【Abstract】Objective To research the clinical effect of ticagrelor and clopidogrel in treating ACS patients. Methods Divided 70 ACS patients into 2 groups. the 35 patients in control group were given aspirin combined with clopidogrel therapy while the 35 patients in observation group were given aspirin combined with ticagrelor therapy. Compaerd the changed of the level of PAR and hs-CRP between the 2 groups after therapy, recorded the occurrence of endpoint events and adverse reactions of the 2 groups during therapy. Results The level of PAR and hs-CRP before therapy between the 2 groups had no significant difference(Pgt;0.05), the level of PAR and hs-CRP of 1d, 7d and 28d after therapy of observation group were all significantly lower than control group(Plt;0.01). The rate of the occurrence of endpoint events in observation group 5.71% was significantly lower than control group 22.86%(Plt;0.01) while the rate of adverse reactions between the 2 groups had no significant difference(Pgt;0.05). Conclusion Aspirin combined with ticagrelor has the advantages of significant platelet inhibition and remarkable clinical effect in treating ACS. 　　【Ke