替比夫定与干扰素治疗慢性乙型肝炎的对比研究.docVIP

精品论文 参考文献 替比夫定与干扰素治疗慢性乙型肝炎的对比研究 武汉市黄陂区人民医院感染科 湖北武汉 430300 【摘 要】目的：探究替比夫定与干扰素治疗慢性乙型肝炎的临床疗效。方法：将我院2014年3月--2015年6月之间收录的118例慢性乙型肝炎患者随机的分为两组，A组59例患者在常规的治疗基础上采取替比夫定进行治疗，而B组的59例患者在常规的治疗基础上采取干扰素进行治疗，两组的患者均治疗12个月，其中治疗6个月后无治疗应答的患者进行停药观察。结果：通过两组的治疗效果分析，其中A组患者在治疗后ALT复常率和HBV-DNA阴转率以及HBeAg转换率均明显的高于B组的情况，两组的数据比较具有显著性的差异（Plt;0.05），统计学有意义；A组患者在治疗的过程中出现的不良反应发生率明显的低于对照组治疗过程中出现的不良反应情况，而且两组的数据比较具有显著性的差异（Plt;0.05），统计学有意义。结论：在慢性乙型肝炎的临床治疗中采取替比夫定治疗比干扰素治疗更具有较好的抗毒效果，出现的不良反应也少，值得临床中应用。 【关键词】替比夫定；干扰素；慢性乙型肝炎；对比分析 [Abstract] Objective：To explore the clinical curative effect of telbivudine and interferon in the treatment of chronic hepatitis B. Methods：in our hospital in March 2014 - 2015 years 6 months included 118 cases of chronic hepatitis B patients randomly divided into two groups，a group of 59 patients in the conventional treatment on the basis of taking telbivudine treatment，and group B of the 59 patients in the conventional treatment on the basis of to take interferon treatment，the patients in the two groups were treated for 12 months. The treatment for 6 months after no response to treatment in patients with discontinuations were observed. Results：through the analysis of the therapeutic effect of the two groups，which a group of patients after treatment，ALT recovery rate and HBV-DNA negative conversion rate and HBeAg conversion rate were significantly higher than the group B，two groups of data compared with significant differences（P lt; 0.05），with statistical significance；incidence of a group of patients in the treatment process of adverse reaction rate was significantly lower than that in the control group during the treatment of adverse reactions and two groups of data compared with significant differences（P lt; 0.05），with statistical significance. Conclusion：in the clinical treatment of chronic hepatitis B take telbivudine treatment than interferon treatment is more good antitoxic effect，less adverse reactions，it is worthy of clinical application. [keyword] telbivudine；interferon；c