来士普治疗老年抑郁症患者的疗效观察.docVIP

精品论文 参考文献 来士普治疗老年抑郁症患者的疗效观察 黄玲1 向香义2 谢静3 1 广西壮族自治区人民医院 心理门诊 2 武警水电第一总队医院 内科 3柳州市柳铁中心医院 心理门诊 【摘要】目的：探讨来士普治疗老年抑郁症患者的疗效及其临床应用价值。方法：将138 例在本院治疗的老年抑郁症患者随机分为两组进行双盲对照实验， 每组69 例，对照组给予阿普唑仑治疗，观察组给予来士普治疗，疗程为6 周，以汉密尔顿抑郁量表( HAMD) 和治疗中出的症状量表(TESS) 评定治疗效果。结果： 观察组的有效率和总有效率为79.7%和94.2%，显著高于对照组的65.2%和85.5%( Plt; 0.05)。两组患者在治疗前HAMD、HAMA 评分无显著差异( Pgt;0.05 )。治疗 组患者在治疗两周后的HAMD、HAMA 评分出现显著下降( Plt; 0.05) ，而对照组在治疗4 周后出现了显著下降( Plt; 0.05)。对照组的不良反应发生率显著高于观察 组( Plt; 0.05)。结论：来士普治疗老年抑郁症患者的临床疗效较好，起效快，安全性高，能有效改善患者的抑郁状态，值得临床推广应用。 关键词：来士普；抑郁症；疗效 Observation on the clinical efficacy of lexapro in the treatment of elderly patients with depression [Abstract] Objective: To explore the clinical efficacy of lexapro in the treatment of senile depression and its clinical application value. Methods: 138 cases of the elderly patients with depression under double-blind trial in our hospital were randomly divided into two groups, 69 patients in each group, the control group was given alprazolam treatment, the observation group was given lexapro treatment, the treatment was lasting for 6 weeks, the clinical effect was evaluated with Hamilton Depression Scale (HAMD) symptom of the table and treatment (TESS). Results: The efficiency rate and total efficiency rate in observation group were 79.7% and 94.2%, significantly higher than those of the control group 65.2% and 85.5% (Plt; 0.05). No significant difference in HAMD, HAMA score of two groups before and after treatment (Pgt;0.05). The HAMD, HAMA score in treatment group patients decreased significantly in two weeks after the treatment (Plt; 0.05), while the HAMD, HAMA score in the control group had significantly decreased in 4 weeks after treatment (Plt; 0.05). Adverse reactions in the control group were significantly higher than those of the observation group (Plt; 0.05). Conclusions: Lexapro in the treatment of senile depression has a rapid clinical efficacy with high safety, which could effectively improve the depression in