氨溴索注射液治疗对呼吸窘迫综合征新生儿血浆内皮素-1(ET-1)水平的影响研究.docVIP

精品论文 参考文献 氨溴索注射液治疗对呼吸窘迫综合征新生儿血浆内皮素-1(ET-1)水平的影响研究 陈锋 　　新津县人民医院 儿科 四川成都 611430 　　【摘要】 目的：探讨氨溴索注射液治疗对呼吸窘迫综合征新生儿血浆内皮素-1(ET-1)水平的影响 方法：选取2010年9月～2016年1月我院收治的诊断为新生儿ARDS的患儿共66例，按照随机数字法分为观察组和对照组，两组各33例。对照组在常规治疗基础上实施机械通气、抗感染及支持治疗；观察组患者在对照组治疗基础上加用氨溴索注射液。两组患儿分别于治疗前和治疗后第5天抽取动脉血和静脉血分别来测量综合指数以及ET-1水平。结果：在治疗第5天，两组ET-1水平显著低于治疗前，且观察组ET-1（40.09plusmn;10.36）水平改善程度显著优于对照组（49.13plusmn;9.75），差异均有统计学意义（Plt;0.05）结论：氨溴索注射液能有效改善呼吸窘迫综合征患儿的氧合状况，降低其血浆内皮素-1水平。 　　【关键词】:氨溴索；呼吸窘迫综合征；新生儿；内皮素-1 　　Ambroxol injection in the treatment of neonatal respiratory distress syndrome plasma angiotensin -1 (ET-1) on the level of influence 　　Chen Feng 　　Department of Pediatric, the Peoplersquo;s Hospital of Xinjin County;Chengdu, Sichuan;611430 　　[Abstract] Objective:Of ambroxol injection in the treatment of respiratory distress syndrome neonatal plasma endothelin-1 (ET-1). Methods: diagnosis of September 2010 to 2016 January in our hospital were selected for a total of 66 cases of neonatal acute respiratory distress syndrome (ARDS) in children, according to randomly divided into observation group and control group, two groups of 33 cases in each group. The control group in the conventional treatment on the basis of implementation of mechanical ventilation, anti infection and supportive treatment; observation group patients in the control group were treated with ambroxol hydrochloride injection. Patients in both groups before treatment and after treatment on the 5th day of arterial and venous blood were measured arterial oxygen partial pressure (PaO2), Alveolar arterial oxygen branch pressure difference (PA-aDO2), oxygen (PaO2 / FiO2) score and the level of ET-1. Results:On the fifth day of treatment, ET-1 levels in two groups were significantly lower than those before treatment, and the observation group of ET-1 (40.09plusmn;10.36) level improved significantly better than the control group (49.13plusmn;975), the differences were statistically significant (Plt;0.05) conclusion: ambroxol injection can effectivel