氯氮平与奥氮平治疗阿尔茨海默病精神症状的临床对照研究.docVIP

精品论文 参考文献 氯氮平与奥氮平治疗阿尔茨海默病精神症状的临床对照研究 孔荣见 余琼芳 　　(云南省曲靖市第三人民医院精神二科 655000) 　　【摘要】目的：对比氯氮平与奥氮平在治疗阿尔茨海默病中对精神症状的疗效与不良反应观察。方法：对23例氯氮平与23例奥氮平治疗有精神病性症状的阿尔茨海默病患者，在治疗0、2、4、8周分别用简明精神病评定量表（BPRS）评定，治疗中用症状量表（TESS）评定，对比两组疗效及不良反应观察。结果：治疗2周时，两组患者BPRS评分均较治疗前显著降低（P均lt;0.05),两组的BPRS评分在不同的治疗时间差异无显著性（Plt;0.05）。2、4、8周时奥氮平组的TESS评分明显低于氯氮平组，两组存在显著差异（Plt;0.05)。结论：氯氮平与奥氮平在治疗阿尔茨海默病的精神症状疗效基本相似，但奥氮平的不良反应明显低于氯氮平。 　　【关键词】氯氮平 奥氮平 阿尔茨海默病 精神症状 　　【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2014）01-0054-02 　　Clinical controlled study of clozapine and olanzapine in the treatment of psychiatric symptoms of Alzheimers disease 　　Kong Rong-Jian,Yu Qiong-Fang,Qujing Third Peoples Hospital of Yunnan Province，Qujing 655000 ,China 　　【Abstract】 objective: to compare the clozapine and olanzapine in the treatment of alzheimers disease to mental symptom curative effect and adverse reactions to observe. Methods: 23 cases of 23 cases of clozapine and olanzapine in treatment of psychotic symptoms of alzheimers patients, in the treatment of 0, 2, 4, 8 weeks, respectively, with the brief psychiatric rating scale (BPRS), treatment with symptoms scale (TESS), compared two groups of curative effect and adverse reaction of observation. Results: two weeks, two groups of patients with BPRS scores were significantly lower than before treatment (P lt; 0.05), two groups of BPRS score there was no significant difference in different treatment time (P lt; 0.05). At 2, 4, 8 weeks TESS scores of olanzapine group was obviously lower than clozapine group, significant differences in the two groups (P lt; 0.05). Conclusion: clozapine and olanzapine in the treatment of alzheimers disease is similar mental symptoms curative effect, adverse reaction of olanzapine significantly lower than clozapine. 　　【Key words】clozapine Olanzapine Alzheimers disease Mental symptoms 　　阿尔茨海默病（AD），主要临床相为痴呆综合征,常在40-90岁之间发病，有记忆及其他认知功能损害，常合并有抑郁、焦虑，情感失禁，妄想、幻觉等精神症状[1]，精神症状给临床护理和家庭管理带来很多问题，因此有效控制精神症状成了