慢乙肝患者抗病毒治疗应答差异的tagsnp遗传关联分析.docVIP

IL12A、IL1B、IL17A单核苷酸多态性与慢性乙型肝炎恩替卡韦治疗HBeAg血清学转换的遗传关联研究 (400038 重庆 , 第三军医大学西南医院感全军染病研究所，感染病研究重庆市重点实验室1; 271000山东 泰安，解放军第88医院全军肝病诊治中心2) [摘要] 目的通过遗传关联研究观察慢性HBV感染免疫相关重要细胞因子IL-12、IL-1B、IL-17的基因多态性与恩替卡韦抗病毒治疗HBeAg血清学转换之间的关联。 方法 109例恩替卡韦抗病毒治疗的HBeAg阳性慢性乙型肝炎患者, 治疗24个月时HBeAg血清学转换29例，未转换80例；分析IL12A rs568408、IL1B rs1143623、IL17A rs8193036基因型与HBeAg血清学转换之间的关联。 结果 IL-12A rs568408与HBeAg血清学转换显著相关,GA基因型发生 HBeAg 血清转换的易感性显著高于GG基因型 [OR=3.72 (1.3410.32)，P=0.012]。未发现IL-1B rs1143623 [OR=1.99 (0.725.44), P=0.17] 和IL-17A rs8193036 [OR=1.54 (0.327.33), P=0.60] 与HBeAg血清学转换存在关联。 结论 IL-12A rs568408与慢性乙型肝炎恩替卡韦治疗HBeAg血清学转换存在关联。 关键词 乙型肝炎慢性恩替卡韦单核苷酸多态性HBeAg血清学转换Association between IL12A, IL1B and IL17A polymorphisms and HBeAg seroconversion in chronic hepatitis B patients who received entecavir treatment Wu Junqiu 1, He Dengming 2, Yan Zehui 1, Tao Shiqi 1, Xu Cheng 1, Zhu Peng1,Wang Yuming 1（1 The Chongqing Key Laboratory For Research of Infectious Diseases,Chongqing, 400038，Department of Infectious Diseases, Southwest Hospital, The Third Military Medical University；2 Liver Disease Diagnoses and Treatment Center, the 88th Hospital of Chinese PLA, Taian, 271000） [Abstract] Objective Host genetic factor is one of important reasons for different response of antiviral treatment in chronic hepatitis B. IL-12, IL-1B and IL-17 play an important role in immune to HBV. IL12A rs568408, IL1B rs1143623, and IL17A rs8193036 are association with many diseases. The study aimed to observe the association between IL12A, IL1B and IL17A gene polymorphisms and HBeAg seroconversion in chronic hepatitis B patients who received entecavir treatment. Methods IL12A rs568408, IL1B rs1143623, and IL17A rs8193036 were genotyped using the MGB-TaqMan SNP genotyping assay in 109 HBeAg-positive chronic hepatitis B patients who had received entecavir treatment. After 24 months, 29 cases achieved HBeAg seroconversion (response) were assigned as the case and the remaining 80 cases were assigned as the control. SNPstats was ap