益生菌联合早期肠内营养对急性重症脑卒中患者肺部感染发生率的影响.docVIP

精品论文 参考文献 益生菌联合早期肠内营养对急性重症脑卒中患者肺部感染发生率的影响 河北医科大学第二医院，河北石家庄，邮编：050000 [摘要]目的 观察益生菌联合早期肠内营养对急性重症脑卒中患者肺部感染发生率的影响。方法 本研究选取2015年1月至2015年12月在我院神经内科重症监护病房住院的114例脑卒中患者进行研究，随机数字法将患者分为干预组和对照组各57例，对照组患者入院48h内置鼻饲管，肠内营养制剂给予营养科肠内高营养治疗 200ml/次，3/日。干预组采用力存益生菌颗粒（上海励成营养产品科技股份有限公司） 2g采用温水化开鼻饲管注入，2次/日+肠内高营养治疗200ml/次 3/日。两组应用时间均为15d。观察两组肺部感染发生率、血清总蛋白（TP）、前白蛋白(PA)水平及腹胀、腹泻等胃肠并发症发生率。结果 干预组肺部感染率为22.81%，对照组为42.11%，差异有统计学意义（p＜0.05）。两组干预后TP、PA水平均较干预前有明显改善（p＜0.05），干预组改善效果更明显（p＜0.05）。干预组腹胀发生率为10.52%，对照组发生率为29.82%，差异有统计学意义（p＜0.05）；干预组腹泻发生率为7.02%，对照组为22.81%，差异有统计学意义（p＜0.05）；干预组便秘发生率为5.26%，对照组为15.79%，差异无统计学意义（p＞0.05）。结论 益生菌联合早期肠内营养可降低重症脑卒中患者肺部感染的发生率，可能与益生菌可有效维护胃肠功能、改善营养状态等有关。 [关键词]肠内营养；益生菌；脑卒中；获得性肺感染 Effect of probiotics combined with early enteral nutrition on the incidence of pulmonary infection in patients with acute severe stroke [Abstract]Objective To study the effect of probiotics combined with early enteral nutrition on the incidence of pulmonary infection in patients with acute severe stroke. Methods 114 patients with acute severe stroke in neurological intensive care unit of our hospital from January 2015 to December 2015 were studied. Patients were randomly divided into intervention group and control group with 57 patients each group.Within 48h after admission, the control group were treated with nasogastric tube and received enteral high nutrition with 200ml/ times, 3 times / day. Intervention group received Revilife probiotic granules (Shanghai Richeng Nutrition Co., Ltd) 2g by warm water to open the nasal feeding tube injection based on control group. The application time of the two groups was 15d. Incidence rate of pulmonary infection, serum total protein (TP), pre albumin (PA), abdominal distension, diarrhea and other gastrointestinal complications in two groups were observed. Results The incidence rate of pulmonary infection in intervention group and control group were 22.81% and 42.11%, respectively, and the difference was statistically significant between two groups(P lt; 0.0