米索前列醇舌下含服终止早期妊娠的前瞻性临床分析.docVIP

精品论文 参考文献 米索前列醇舌下含服终止早期妊娠的前瞻性临床分析 林蕾 郑玉华（通讯作者） 潘淑芬 李军煜 王玉玲 （广东省佛山市妇幼保健院妇科 528000） 【摘要】目的 探讨米索前列醇舌下给药用于药物流产的有效性和安全性。方法　采用前瞻性随机对照临床研究，将500例孕龄le;7周要求终止妊娠的孕妇随机分组，米非司酮150mg，分次口服，48小时后研究组舌下含服米索前列醇400mu;g，对照组口服米索前列醇600mu;g，之后留院观察6小时。定期随诊，观察治疗结局。结果　舌下组与口服组的完全流产率分为94.8%（237/250）及91.2%（228/250），两组比较无统计学差异（Pgt;0.05），但孕囊排出时间舌下组明显短于口服组，而口服组平均用药剂量明显高于舌下组（Plt;0.01）。舌下组妇女阴道出血量明显少于口服组（Plt;0.01），但阴道出血持续时间两组比较无显著性差异（Pgt;0.05）。舌下组恶心、呕吐及腹泻的发生率明显低于口服组（Plt;0.01），其它副反应比较无显著性差异（Pgt;0.05）。结论　米索前列醇经舌下给药的药物流产效果优于口服给药，未明显增加副作用，能更好地节约药品资源，值得临床推广。 【关键词】 米非司酮 米索前列醇 舌下含服 早期妊娠 流产 【中图分类号】R714 【文献标识码】A 【文章编号】2095-1752（2013）29-0106-02 Prospective randomized controlled clinical study of effects of sublingual misoprostol on medical abortion Lin Lei, Zheng Yuhua, Pan Shufen, Li Junyu, Wang Yuling. Maternal and Child Health Hospital of Foshan, Foshan 528000, Guangdong, China Corresponding author：Zheng Yuhua E-mail: linlei_nf@163.com 【Abstract】 Objective: To study the efficacy and safety of sublingual misoprostol in patients with medical abortion. Methods : five hundred gravidas up to 7 weeks gestation were randomized into two groups and given 400mu;g of misoprostol sublingually and 600mu;g of misoprostol orally 48 hours later combined with Mifepristone (150mg). All were observed for 6 hours after taking misoprostol and returned for assessment on time. Results : complete abortion occurred in 94.8% of women in the sublingual group and 91.2% in the oral group showing no statistically significant difference (Pgt;0.05). The mean induction- to- abortion intervals in the sublingual group were significantly shorter than in the oral group (Plt;0.01). And the average dose in the oral group were significantly higher than in the sublingual group (Plt;0.01). The amount of vaginal bleeding in the sublingual group was significantly less than in the oral group. There was no significant difference in the average interval of vaginal bleeding after treatment betw