美托洛尔联合曲美他嗪治疗冠心病心力衰竭患者临床效果分析 何文华.docVIP

精品论文 参考文献 美托洛尔联合曲美他嗪治疗冠心病心力衰竭患者临床效果分析 何文华 湖南省郴州市第一人民医院 423000 【摘 要】目的：研究美托洛尔联合曲美他嗪治疗冠心病心力衰竭患者临床效果。方法：选择我院2014年4月-2015年1月就诊的83例冠心病心力衰竭患者。随机将83例患者分为M组和M+Q组。M组仅给予美托洛尔治疗；M+Q组给予美托洛尔联合曲美他嗪治疗。比较（1）临床疗效；（2）用药副作用；（3）干预前和干预后患者脑钠肽、6分钟步行距离、左心射血分数的差异。结果：（1）M+Q组对比M组临床疗效更高，P＜0.05；（2）两组均无严重副作用，P＞0.05；（3）干预前两组脑钠肽、6分钟步行距离、左心射血分数相似，P＞0.05；干预后M+Q组对比M组脑钠肽、6分钟步行距离、左心射血分数改善更显著，P＜0.05。结论：美托洛尔联合曲美他嗪治疗冠心病心力衰竭患者临床效果确切，可有效改善患者心功能，用药安全，是一种理想治疗方式。 【关键词】美托洛尔;曲美他嗪;冠心病心力衰竭患者;临床效果 【 abstract 】 objective： to study the metoprolol combined trimetazidine treatment of heart failure patients with coronary heart disease clinical effect.Methods： from April 2014 - January 2015 of 83 cases of coronary heart disease（CHD）patients with heart failure.83 patients were randomly divided into group M and M + Q group.M group limited to metoprolol therapy; M + Q group was given metoprolol combined trimetazidine treatment.（1）the clinical curative effect;（2）drug side effects;（3）the intervention before and after intervention in patients with brain natriuretic peptide，6 minutes walking distance，the difference of left heart ejection fraction.Results：（1）M + Q group contrast clinical curative effect of higher M group，P lt; 0.05;（2）in the two groups were no serious side effects，P gt; 0.05;（3）the intervention in the first two group of brain natriuretic peptide，6 minutes walking distance，similar to left heart ejection fraction，P gt; 0.05; M + Q after intervention group contrast M brain natriuretic peptide，6 minutes walking distance，left heart ejection fraction improved more significantly，P lt; 0.05）.Conclusion： metoprolol combined trimetazidine treatment of heart failure patients with coronary heart disease clinical effect，can effectively improve cardiac function in patients with，drug safety，is an ideal treatment method. 【 key words 】 metoprolol; Trimetazidine.Coronary heart disease（CHD）in patients with heart failure; Clinical effect 冠心病为冠脉粥样硬化导致心血管阻塞而引发心肌缺血缺氧的一种心脏病，发病率高。心力衰竭为冠心病