MicroRNAs与心肌细胞肌浆网钙操纵功能调控-中国细胞生物学学报.PDFVIP

网络出版时间：2015-06-02 17:25 网络出版地址：/kcms/detail/31.2035.Q1725.001.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(6): DOI: 10.11844/cj cb.2015.06.0398 MicroRNAs与心肌细胞肌浆网钙操纵功能调控 崔玉荣 尹盟盟 孙小夕 洪 鲜 罗雪颖 钟彬龙 席姣娅* (华中科技大学同济医学院基础医学院生理学系, 脑研究所, 药物靶点研究与药效学评价湖北省重点实验室, 武汉430030) 摘要 肌浆网(sarcoplasmic reticulum, SR)钙操纵功能是心肌细胞发生、发育及成熟的重要 环节之一, 是心肌收缩维持心脏泵血的功能基础。多种心脏疾病发生发展与SR钙操纵功能的紊乱 有关。研究表明, microRNAs(miRNAs) 以多种作用途径参与心肌细胞SR钙操纵功能的调节以及心 脏疾病的发生发展或者心脏功能的保护。该文主要围绕miRNAs调控心肌细胞SR钙操纵及其机制 的研究现状作一综述, 并对miRNAs在心脏疾病的临床诊断和治疗中的运用前景进行展望。 关键词 microRNAs; 心肌细胞; 肌浆网; 钙操纵 MicroRNAs and Its Functional Regulation on Calcium Handling of Cardiac Sarcoplasmic Reticulum Cui Yurong, Yin Mengmeng, Sun Xiaoxi, Hong Xian, Luo Xueying, Zhong binlong, XI Jiaoya* (Department of Physiology and Institute for Brain Research, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, the Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China) Abstract The properties of sarcoplasmic reticulum (SR) calcium handling are crucial for differentiation, development and maturation of cardiomyocytes, and are also the basic for cardiac contraction and heart pumping. Lots of heart diseases are related to the dysfunction of SR calcium handling. Accumulated data were amassed showing that microRNAs (miRNAs) participated and played important role in regulating cardiac SR calcium handling, and contributed to some heart