苯磺酸氨氯地平对老年高血压二型糖尿病型心肌病的早期影响.docVIP

精品论文 参考文献 苯磺酸氨氯地平对老年高血压二型糖尿病型心肌病的早期影响 薛静蓉（北京市北医三院中央党校院区 100091） 【摘 要】 目的 探讨苯磺酸氨氯地平对老年高血压2 型糖尿病心肌病左室舒张功能减退的影响。方法 2型糖尿病高血压心肌病患者40 例，按1：1比例随机分为两组，治疗组在常规降糖药物治疗的同时加用苯磺酸氨氯地平5 mg，1 次/日，疗程3 个月。在治疗前后所有受试者均作超声心动图，心电图相关指标测定。结果 治疗组治疗后的血压.左室舒张功能及T波。其中12 例恢复正常，6 例好转，2 例无效，有效率为90%，对照组无明显变化。两组治疗前后有明显的差异。结论 苯磺酸氨氯地平可改善老年高血压2型糖尿病心肌病变，使T波恢复。左室舒张功能恢复. 【关键词】 苯磺酸氨氯地平；高血压；II型糖尿病性心肌病；左室舒张功能减退 Early impact of amlodipine on elderly hypertensive patients accompanied with cardiomyopathy and type 2 diabetes. XUE Jing—rong. [Abstract] Objective To discuss the influences of amlodipine on the left ventricular diastolic dysfunction of elderly hypertensive patients accompanied with cardiomyopathy and type 2 diabetes. Methods 40 patients accompanied with cardiomyopathy and type 2 diabetes were randomly divided into 2 groups according to 1：1. In addition to conventional hypoglycemic agents, amlodipine intervention group were treated with amlodipine besylate tablets (5mg) once per day for 3 months. All the patients from both groups underwent echocardiography and ECG-related parameters were measured before and after 3 months treatment. Results After treatment with amlodipine, 12 subjects of amlodipine intervention group showed significant improvement in blood pressure, left ventricular diastolic function and T wave. Furthermore 6 subjects got amelioration without significance and 2 showed no improvement in the same group. Compared with that of 3 months ago, additional treatment with amlodipine showed 90% efficiency. There has been significant difference between intervention group and control group after 3 months treatment. Conclusion Treatment with amlodipine may improve the left ventricular diastolic function and T wave of elderly hypertensive patients accompanied with cardiomyopathy and type 2 diabetes. [Keywords] Amlodipine; Hypertension type; 2 diabetes; Cardiomyopathy diastolic 1 资料与方法 选择1997～2010 年住院病人16 例，门诊病人24 例。年龄在54～80 岁，平均年龄，60plusmn;2.3 岁。病程5～10 年。均符合1999 年WH