药物去势与手术去势治疗中晚期前列腺癌患者效果及并发症分析.docVIP

精品论文 参考文献 药物去势与手术去势治疗中晚期前列腺癌患者效果及并发症分析 吕东 黄翔 邱明星 　　（四川省人民医院泌尿外科 四川 成都 610072） 　　【摘要】目的：回顾性分析药物去势与手术去势对中晚期前列腺癌患者效果及并发症差异。方法：2008年5月至2013年3月采用药物去势48例（A组）与手术去势51例（B组）治疗中晚期前列腺癌，予以随访观察，分析其症状改善情况、生存时间、并发症及心理的影响等。结果：药物去势组和手术去势组都能提高患者总体生存时间、改善患者生活质量，治疗效果无明显差异，但相关并发症存在一定的差异。结论：药物去势和手术去势对中晚期前列腺癌患者的治疗都是有效的，但手术去势存在手术相关并发症及对生活质量影响较大，所以药物去势治疗应作为中晚期前列腺癌的首选治疗。 　　【关键词】中晚期前列腺癌; 药物去势; 手术去势; 生活质量 　　【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2015）12-0095-03 　　Effects and complications study of medical castration verus surgical castration in the treatment of advanced prostate cancer 　　Lv Dong, Huang Xiang, Qiu Mingxing Sichuan Provincial Peoples Hospital, Chengdu 610072,China 　　【Abstract】Objective A retrospective analysis of medical castration in patients with surgical castration differences in effects and complications of advanced prostate cancer. Methods From May 2008 to March 2013 using medical castration 48 cases (A group) and 51 cases of surgical castration (group B) the treatment of advanced prostate cancer to be followed up, analyze their improvement of symptoms, survival, complications and psychological impact, etc. Results Medical castration group and surgical castration group can improve overall survival time and improve the quality of life of patients, no significant difference in treatment effect, but there are some differences related complications. Conclusion Medical castration and surgical castration for the treatment of patients with advanced prostate cancer are effective, surgery-related complications and a greater impact on quality of life but there are surgical castration, so medical castration therapy should be used as the first choice for advanced prostate cancer treatment. 　　【Key words】 Advanced prostate cancer; Medical castration; Surgical castration; Quality of life 　　前列腺癌发病率存在明显的地理及种族差异，总体欧美发病率较高，亚洲发病率较低，由于医疗水平及就医环境的提高我国前列腺癌检出率呈明显上升趋势，但由于认识水平及经济等原因，特别是农村地区或不发达地区，多数患者就诊时已经发展为中晚期前列腺癌，失去根治性前列腺切除的机会。外科治疗肿瘤更多的是采用手术治疗，但如果因为患