强直-阵挛发作对成人癫痫患者骨密度的影响Effect of tonic - clonic seizures on bone mineral density in adults with epilepsy.pdfVIP
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强直-阵挛发作对成人癫痫患者骨密度的影响Effect of tonic - clonic seizures on bone mineral density in adults with epilepsy
南昌大学
硕士学位论文
强直-阵挛发作对成人癫痫患者骨密度的影响
姓名:戴为正
申请学位级别:硕士
专业:神经病学
指导教师:张明
201106
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摘要
摘 要
tonicclonic
目的分析发作类型为强直~阵挛发作(generalizedseizure,GTCS)
mineral
的未服抗癫痫药的成人癫痫患者骨密度(bone density,BMD)的变化,探讨
影响强直一阵挛发作患者骨密度变化因素。
方法对29名发作类型为强直一阵挛发作且未曾服用任何抗癫痫药的癫痫
患者和30名健康成人进行骨密度检测并予以对比,对强直一阵挛发作患者总碱
性磷酸酶、血磷浓度以及血钙浓度进行检测分析。
结果强直一阵挛组癫痫患者L1至L4椎体总体平均骨密度Z值明显较正常
对照组低伊=0.007)。对强直~阵挛患者的年龄、性别、病程、体重等因素与其
骨密度进行相关性分析,发现体重和性别存在相关性。患者腰椎部骨密度与体
度Z值与性别关系为(B一0.38,P=0.009),即与女性成『F相关,与男性成负相
关。
结论强直一阵挛发作可导致成人癫痫患者骨密减低,体重是保护性因素,
女性较男性受影响小。
【关键词】: 强直一阵挛发作; 癫痫; 骨密度;DEXA
II
Abstract
——————————————————————————————————————一一_
ABSTRACT
To the
Objective ofbone
investigate mineral of
change aduItswhohas
density
epi totonic’chronicseizures
lepsybelongs without analyzethe
antiepilepticdrug,and
relatedfactors
influenceonbone
mineral
density.
MethodsBone
mineral of
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