止咳胶囊治疗咳嗽变异性哮喘气阴两虚型的临床研究Clinical study of Zhike capsule in the treatment of cough variant asthma with two deficiency of Qi and Yin.pdf

提 要 目的：观察及评价止咳胶囊治疗咳嗽变异性哮喘气阴两虚型的安全性及有效性， 并探讨其作用机理。方法：临床选择符合纳入标准者 60 例，随机分为治疗组（30 例） 与对照组（30 例），治疗组口服止咳胶囊配合多索茶碱和吸入布地奈德干粉吸入剂， 对照组口服多索茶碱和吸入布地奈德干粉吸入剂，疗程均为 4 周，观察治疗前后临床 症状和实验室检查指标的变化。结果：临床研究显示：治疗组总有效率 93.33%，显 著优于对照组（P0.05 ），提示止咳胶囊具有减轻气道炎症、降低气道高反应性，改 善和调节肺功能的作用。结论：益气养阴法是治疗咳嗽变异性哮喘的有效方法，可改 善患者的症状、体征，防止其进一步发展成典型哮喘。 关键词 益气养阴法；咳嗽变异性哮喘；气阴两虚型；临床研究 The Clinical Study on Treating Cough Variant Asthma of Qi and Yin deficiency with Cough capsule Speciality: The Study of Lung Disease Internal Medicine of TCM Author: Chen Yangkai Tutor: Professor Chen Xianhai Abstract Objective:To observe and evaluate the cilnical security and validity of Cough capsule in treating Cough Variant Asthma (which belongs to Qi and Yin deficiency type in TCM) and explore the mechanism of it. Methods: 60 patients were divided into two groups at random. 30 patients in observation group were treated with Cough capsule plus Doxofylline and Budesonide. 30 patients in control group were treated with Doxofylline and Budesonide. The related items were measured before and after the treatment.Results:The clinical study showed that there is a significant difference （P0.05 ） between the two groups.The effect of relieving airway inflammation,reducing the airway hyper-reaction and lung function and immunoregulation were improved more significantly in the treatment group than that in the control group. Conclusions: Cough capsule is an effective medicament of treating Cough Variant Asthma which can mdoderate the clinical sumptoms and prenvent it from transforming to asthma. Key words Yiqiyangyin Method ；Cough Variant Asthma ；Qi and Yin deficiency type；Clinical study 目 录 引 言 1 临床研究 2 一、临床研究 2 （一）诊断标准 2 （二）病例选择 2 （三）中医单项