诊断性刮宫术后应用炔诺酮治疗更年期功能失调性子宫出血的临床效果分析.docVIP

精品论文 参考文献 诊断性刮宫术后应用炔诺酮治疗更年期功能失调性子宫出血的临床效果分析 赵彦雷（嘉祥县人民医院妇科，山东济宁 272400） 【摘要】目的：观察诊断性刮宫术后联合应用炔诺酮治疗更年期功能失调性子宫出血的临床疗效和安全性。方法：2011年11月—2015年10月，选取我院更年期功能性失调性子宫出血患者共126例，随机分为两组，对照组60例，使用米非司酮内科保守治疗；观察组66例，使用诊刮术加药物炔诺酮治疗。观察用药期间阴道流血情况及子宫内膜厚度变化。结果：统计学分析比较显示观察组治愈率78.9％，对照组治愈率为66.7%，总治愈率两组间比较差异具有显著性(Plt;0.05)；两组治疗前后子宫内膜厚度均变薄，治疗后观察组较对照组的子宫内膜薄，差异具有统计学意义(Plt;0．05)。结论：诊刮术联合炔诺酮治疗更年期功血患者，疗效确切，子宫恢复情况好，不失为治疗更年期功血的一种有效方法。 【关键词】更年期；功能失调性子宫出血；米非司酮；炔诺酮；临床效果 【Abstract】Objective: to observe the diagnostic curettage surgery combined use of norethindrone treating climacteric dysfunctional uterine bleeding of clinical efficacy and safety. Methods: in November 2011 - in October 2015, selected from menopause, a total of 126 patients with functional loss of uterine bleeding, randomly divided into two groups, control group 60 cases, the use of mifepristone internal medicine conservative treatment; Observation group 66 examples, using the diagnosis norethindrone plus drug therapy. Observed during vaginal bleeding and endometrial thickness changes. Results: statistical analysis and comparison shows group cure rate 78.9%, control group cure rate was 66.7%, the total cure rate comparison between the two groups have significant difference (P lt; 0.05); The two groups before and after treatment of endometrial thickness thinning, observation group than the control group after treatment of endometrial thin, statistically significant difference (P lt; 0.05). Conclusion: the clinical surgery combined therapy with norethindrone menopausal patients function, curative effect, uterine recovery is good, can yet be regarded as an effective method for the treatment of menopausal function. 【key words】menopause; Dysfunctional uterine bleeding. Mifepristone; Norethindrone. Clinical effect 更年期功能失调性子宫出血，是更年期妇女的最常见疾病之一。女性更年期是指卵巢功能开始衰退至绝经后1年内的时期，整个时期需要几年甚至十几年时间，这一时期发生的月经失调主要表现为无排卵性功能失调性子宫出血[1]。更年期功能性子宫出血传统上主要采用孕激素治疗，如炔诺酮(norethisterone，NET)、米非司酮(mifepristone，RU486)、安宫黄体酮等。近几年来我院采用诊断性刮宫(诊刮)术后联合应用炔诺酮治疗更年期功能性子宫出血患者，取得