主动脉瓣发展PPT.ppt

Practical and Engineering Considerations in Catheter-based Aortic Valve Development;Percutaneous Valve Design Requirements;Delivery Size (!);Packing size:“putting 5 gm in a 2 gm bag”;Available Internal CSA Based on Guide Catheter Outer Diameter;Packed CSA for Valve Cuff or Stent;Packed valve CSA v. Delivery Catheter CSA;Big Delivery Catheters = Big Problems;Approaches to reducing delivery size;HLT Valve: 15.5 Fr Delivery System;Percutaneous Valve Design Requirements;Anatomy of the Aortic Valvethe crowded neighborhood;Anatomy of the Aortic Valvethe crowded neighborhood;Deployment Interference;Coronary obstruction;Percutaneous Valve Design Requirements;The Major Displacement Load is During Diastole;Calculation of maximal valve load;Valve obstruction leads to massive forward force on the valve;Testing “Stickability”;Percutaneous Valve Design Requirements;Parameters of Valve Function;What is the minimal EOA?patient prosthesis mismatch;The geometry of stenotic aortic valves varies: the new valve must fit the orifice;Aortic insufficiency due to valve-orifice mismatch;Aortic insufficiency due to valve-orifice mismatch;Blood Flow Through the Aortic Valve;Percutaneous Valve Design Requirements;Biological materials used for heart valves;Stent or Cuff Materials;Nitinol;Valve Durability- In-Vitro Testing;Animal Models of Aortic Stenosis;Clinical Testing;Evolution of Approvals;No-option Patients;Comparison of Percutaneous Aortic Valves;Is this a replay of early surgical valve development?