心衰中的炎症-课件，幻灯，PPT (英文）PPT.ppt

1 Inflammation in heart failure Liao Yu-Hua Institute of Cardiology Union Hospital Huazhong University of Science and Technology, Wuhan China 2 Cognitive process of pathophysiology and therapy in haert failure 3 Inflammation and Heart failure Interaction between neuroendocrine and cytokines in heart failure therapy between inflammation and heart failure 4 β-adrenergic stimulation induces proinflammatory cytokine expression in myocardium *P0.01, **P0.0001 vs saline-treated animals. Murray et al. Circulation. 2000;101:2338-2341. In control myocardium, TNF-a,IL-1b and IL-6 were not detected. Isoproterenol infusion significantly increased expression of all 3 cytokines, indicating that chronic β-adrenergic stimulation was associated with proinflammatory cytokine expression. 5 Causal relationship between Ang II and TGF-β1 in cardiac hypertrophy Schultz JEJ, et al. J Clin Invest 2002;109:787– 96 The lack of the TGFβ1 gene fully prevented the development of cardiac hypertrophy induced by subpressor doses of Ang II that was observed in wild type mice Ang II-induced cardiac hypertrophy is mediated by TGF-β1 8 Angiotensin II induced activation of NF-ĸB Kalra D, et al. Circulation 2002; 105:2198– 205. Stimulation with Ang II lead to a rapid increase in NF-κB binding activity in isolated buffer perfused hearts, the finding suggest a possible pathway in Ang II mediated TNF biosynthesis 9 Cross-regulation between the renin-angiotensin system andinflammatory mediators K. Sekiguchi et al. Cardiovascular Research 2004； 63： 433–442 There is a complicated network in heart failure between neuroendocrine system and immune system Ang II provokes inflammatory responses in the heart through an NF-κB dependent pathway, whereas TNF provoke activation of the RAS in the heart through increased ACE activity. Both of these pathways converge on overlapping MAPK signal transduction pathways 10 Inflammation and Heart failure Interaction between neuroendocrine and cytokines in heart fai