超氧化物歧化酶(SOD)水平变化在阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍发生中的作用.docVIP

精品论文 参考文献 超氧化物歧化酶(SOD)水平变化在阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍发生中的作用 张连勇 张骞云 吴坎金 李晓娟 于金香 宫艳格 　　沧州市中心医院 河北沧州 061001 　　【摘 要】目的：研究超氧化物歧化酶水平变化在阻塞性睡眠呼吸暂停低通气综合症患者认知功能障碍中发生的作用。方法：选择2010年1月至2014年在我院就诊的患者120例，其中诊断为重度OSAHS的患者共计60例做为观察组，选择同一时期，同一年龄段的健康人60例做为对照组，对两组患者进行血清学检测，和蒙特利尔认知功能评分，对比两组患者血清中SOD浓度差异，以及认知功能情况。结果：观察者的MDA、NO水平明显高于对照组，而SOD水平明显低于对照组，各组数据均有统计学差异（Plt;0.05）。经过蒙特利尔评分测试，观察组的延迟记忆、计算力、词语流畅性以及总分明显低于对照组，且具有统计学差异（Plt;0.05），视结构技能、定向力两组无统计学差异（Pgt;0.05）。结论：OSAHS患者认知功能受到损伤可能是由于患者血液中MDA、NO水平升高，SOD水平下降引起的。 　　【关键词】超氧化物歧化酶；阻塞性睡眠呼吸暂停低通气综合症；认知功能障碍 　　【中图分类号】R563.8 【文献标识码】B 【文章编号】1674-8999（2015）9-0569-02 　　The role of superoxide dismutase (SOD) levels change in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) in cognitive dysfunction happened 　　Zhang lian yong,zhang qian yun, wu kan jin, li xiao juan,yu jin xiang ,gong yan ge 　　Cangzhou city central hospital He Bei CangZhou,061001 　　【Abstract】Objective: To research the role of superoxide dismutase (SOD) levels change in patients with obstructive sleep apnea hypopnea syndrome in cognitive dysfunction happened. Methods: Choose between January 2010 and 2014 in our hospital 120 cases of patients. Selected 60 cases as control group which in the same period, the healthy individuals of the same age. Serological tests on two groups of patients, and Montreal cognitive function score, compared two groups of patients with serum SOD concentration difference, and cognitive function. Results: MDA, NO levels of observation group was obviously higher than that of control group, but SOD levels significantly lower than the control group, all the data were statistically significant(Plt;0.05), considered the structure skill, directional force no statistical difference (P＞0.05). Conclusion: Damage cognitive function of patients with OSAHS may be the cause by MDA、NO level rise and SOD level drops in their blood. 　　【Key words】superoxide dismutase (SOD); obstructive sleep apnea hypoventilation syndrome(OSAHA); cognitive dysfunction 　　超