胚胎干细胞体外分化为肝细胞和心肌细胞的研究进展.pdfVIP

- 554 - Drug Evaluation Research 第 37 卷 第 6 期 2014 年 12 月 • 综 述 • 胚胎干细胞体外分化为肝细胞和心肌细胞的研究进展 1 2 2, 3* 张 兴 ，申秀萍 ，刘昌孝 1. 天津中医药大学，天津 300193 2. 天津市新药安全评价研究中心，天津 300193 3. 天津药物研究院 天津药代动力学与药效动力学省部共建国家重点实验室，天津 300193 摘 要：胚胎干细胞是从早期胚胎或原始性腺分离后能在体外长期传代培养的全能细胞系。胚胎干细胞体外可以诱导分化为 各种体细胞，并且用这些体细胞治疗相应的疾病，一直以来是生物医药领域的研究焦点。目前，在该领域用于诱导胚胎干细 胞分化的方法很多，其中的一些方法就用到化合物和部分中药提取物。整理近 5 年来胚胎干细胞体外通过拟胚体途径、细胞 单层诱导分化为肝细胞和心肌细胞的有关文献，做一简要综述。 关键词：胚胎干细胞；生物医药；拟胚体；定向分化 中图分类号：R967 文献标志码：A 文章编号：1674 - 6376 (2014) 06 - 0554 - 04 DOI: 10.7501/j.issn.1674-6376.2014.06.020 Advances in research on in vitro differentiation of embryonic stem cell into liver cells and myocardial cells 1 2 2, 3 ZHANG Xing , SHEN Xiu-ping , LIU Chang-xiao 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianjin Center for Drug Safety Assessment and Research, Tianjin 300193, China 3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Abstract: Embryonic stem cell, separated from the early embryo or the original gonad, is the all-around cell line, which can be well for long-term passages in vitro. Embryonic stem cells can be differentiated into all kinds of somatic cells in vitro and are used to heal relevant serious illnesses. It is a hot spot in the field of study on the embryonic stem cell. It is difficult to find the mechanism, although it is very important. Currently, there are a lot of methods used to induce embryonic stem cells, and some of which are used for the compounds and parts of traditional Chinese medicine extracts. The author has compiled the nearly five years’ literature on embryonic stem cells differentiating into my