辛伐他汀对血管性痴呆患者hs-CRP的影响.docVIP

精品论文 参考文献 辛伐他汀对血管性痴呆患者hs-CRP的影响 张延霞1 郭宗君2 （通讯作者） 王利群1 苏玉文1 　　（1解放军第88医院老年病科 山东青岛 266000) 　　（2青岛大学医学院病附属医院 山东青岛 266000) 　　【摘要】目的 观察辛伐他汀口服对VD患者hs-CRP的影响，并观察治疗前后MMSE评分的变化。 方法 选择2012.5～2013.11我科收治的VD患者60例，分为辛伐他汀治疗组（即治疗组）30例和对照组30例，其中治疗组男22例,女8例；对照组男21例,女9例，两组均给予阿司匹林、尼莫地平及相同的活血化瘀药物等常规治疗及对症处理,治疗组在此基础上给予口服辛伐他汀片，治疗前及治疗后24W行hs-CRP检测及MMSE评分。结果 24W后，治疗组较对照组患者的hs-CRP水平显著降低（Plt;0.05）， MMSE 评分显著升高（Plt;0.05）。结论 辛伐他汀联合阿司匹林、尼莫地平等常规药物治疗血管性痴呆疗效显著， ??明显不良反应，临床中值得推广。 　　【关键词】辛伐他汀 血管性痴呆 hs-CRP 　　【中图分类号】R452 【文献标识码】A 【文章编号】2095-1752（2014）05-0078-02 　　Effect of simvastatin on hs-CRP in patients with vascular dementia ZHANG Yan-xia,SU Yu-wen,WANG Li-qun,SONG Yu-min ,Department of Cadre,the 88th Hospital of PLA,Tairsquo;an,271000,China 　　【Abstract】 Objective To observe the effects of aspirin, simvastatin on VD of patients with hs-CRP, and observe the change of MMSE score before and after treatment. Methods Choose 2012.5 to 2013.11 in our hospital from 60 VD patients, divided into simvastatin group (treatment group) 30 cases and control group 30 cases, the treatment group male 22 cases, female 8 cases; control group, male 21 cases, female 9 cases, the two groups were given aspirin、Nimodipine and the same blood circulation drugs routine treatment and symptomatic treatment, the treatment group based on the given oral Simvastatin Tablets, before treatment and 24W after treatment were detected with hs-CRP and MMSE score. Results 24W later, the treatment group was significantly lower than the control group of patients with hs-CRP (Plt;0.05), MMSE score was significantly increased (Plt;0.05).Conclusion Effect of simvastatin and aspirin、Nimodipine on vascular dementia and other conventional drug treatment significantly, no significant adverse reactions, worthy of promotion in clinical therapy. 　　【Key words】 Simvastatin vascular dementia hs-CRP 　　血管性痴呆( vasculardementia,VD)是由缺血性或出血性脑卒中或缺血缺氧性脑损害导致的以认知损害为特征的综合征[1