阿加曲班注射液在大动脉粥样硬化性脑梗死治疗中的应用体会.docVIP

精品论文 参考文献 阿加曲班注射液在大动脉粥样硬化性脑梗死治疗中的应用体会 佘莉琼 　　（四川省江油市第二人民医院 四川 江油 621700） 　　【摘 要】目的：探讨阿加曲班注射液对大动脉粥样硬化性脑梗死的临床效果、神经功能和炎症因子的影响。方法：选择我院2013年月至2015年1月收治的89例大动脉粥样硬化性脑梗死作为研究对象，按照随机数字表法分为2组，对照组40例给予氯吡格雷片治疗，观察组40例在对照组治疗的基础上加用阿加曲班注射液治疗，治疗14d后比较2组患者的临床疗效及神经功能、炎症因子变化情况。结果：观察组治疗总有效率为91.49%，显著高于对照组的73.81%（P＜0.05）；治疗第7、14d时观察组神经功能缺损评分为（13.15plusmn;2.21）分、（9.08plusmn;1.62）分，均低于对照组（P＜0.05）；治疗第14d时观察组TNF-alpha;、IL-1、IL-6、血小板聚集率、hs-CRP水平显著低于对照组（P＜0.05）。结论：阿加曲班注射液可以显著提高大动脉粥样硬化性脑梗死临床疗效，明显改善了患者神经功能缺损和炎症反应程度，且无严重不良反应发生，值得临床重视。 　　【关键词】大动脉粥样硬化性脑梗死；阿加曲班注射液；神经功能；炎症因子 　　【中图分类号】R543.5 【文献标识码】B 【文章编号】1004-6194（2015）01-0189-02 　　Study on argatroban injection in the treatment of large artery atherosclerotic cerebral infarction 　　【Abstract】Objective To investigate the clinical effect and nerve function and inflammatory factor of argatroban injection in the treatment of large artery atherosclerotic cerebral infarction. Methods 89 cases of large artery atherosclerotic cerebral infarction in in our hospital from January 2013 to January 2015 were selected as the research object,according to the random number table method were divided into two groups,The control group of 40 cases was treated with clopidogrel tablets,the observation group of 40 cases based on the treatment in the control group was treated with argatroban injection.After treatment 14 days,the clinical efficacy and neurological function and inflammatory factors were compared between the two groups.Results The total effective rate in the observation group was( 91.49%) was significantly higher than that of the control group was 73.81% (Plt;0.05); treatment of 7, 14d observation group of neural function defect score for (13.15plusmn;2.21), (908plusmn;1.62), were lower than those of the control group (Plt;0.05); 14d treatment observation group TNF-a, IL-1, IL-6, platelet aggregation rate and hs CRP level was significantly lower than that of control group (Plt;0.05).Conclusion Argatroban injection can significantly improve the lar