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C H A P T E R 50
(
Evidence-Based Regenerative
Injection Therapy (Prolotherapy)
in Sports Medicine
K. Dean Reeves, MD; Bradley D. Fullerton, MD, FAAPMR;
and Gaston Topol, MD
KEY POINTS use of prolotherapy, which is also called regenerative injection ther-
apy (RIT), is expected to greatly accelerate in the next decade. This
. The treatment of sports injuries to the point of restoration of full chapter will cover the pathology of injury; the current treatment meth-
sports performance is an obvious goal in sports medicine. ods and their limitations; and the rationale, basic science, and clinical
However, healing is the preferred goal because returning studies of prolotherapy/RIT. In the latter section, it will also introduce
connective tissue to normal strength allows for a durable return two areas of particularly pertinent research approaches in sports med-
to full sports performance. icine: the treatment of connective-tissue–based, career-threatening
injuries and the use of high-resolution ultrasound to document healing.
. Regenerative injection therapy (prolotherapy) is the injection of
growth fac
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