鳞状上皮细胞癌抗原在宫颈鳞癌中的随访意义.docVIP

精品论文 参考文献 鳞状上皮细胞癌抗原在宫颈鳞癌中的随访意义 贵阳中医学院第一附院 550004 　　【摘要】目的：分析血清鳞状上皮细胞癌抗原（SCC-Ag）在宫颈上皮内瘤样变及宫颈鳞癌治疗前后变化情况，探讨SCC-Ag在宫颈鳞癌患者随访中的临床应用价值。方法：收集病理确诊为CIN（I-III级）患者60例及宫颈鳞癌患者107例（以2009年FIGO分期分为Ia期35例，Ib期41例,IIa期31例），同时选择同期体检健康妇女30例为正常对照组，采用化学发光微粒子免疫分化法（CMIA）测定血清SCC-Ag浓度。结果：1.，正常对照组、CIN I- II组、CINIII之间SCC-Ag阳性率无统计学差异。CINIII、宫颈鳞癌Ia期、宫颈鳞癌Ib期、宫颈鳞癌IIa期之间SCC-Ag阳性率有统计学差异。五组患者SCC-Ag平均值组间比较差异有统计学意义（P＜0.05），且随着宫颈病变程度上升SCC-Ag值呈上升趋势。2.宫颈鳞癌患者治疗后SCC-Ag均值及阳性率明显下降,差异有统计学意义(P＜ 0.05)。术前SCC-Ag阳性患者术后三月转阴率为95.91%，随着随访时间的增加随访时间逐渐增加，治疗后又升高患者有2例均出现复发。结论：1 .血清鳞状上皮细胞癌抗原可作为宫颈鳞癌特异性较高的肿瘤标志物，病变早期血清检查出率低，随着病变升级SCC-Ag值逐步升高，其阳性率也升高，可一定程度上反映病变累计程度及范围。2、宫颈癌术后SCC-Ag水平明显下降，治疗后SCC-Ag下降不满意，或者下降后再升高提示有复发风险， SCCAg值升高出现在临床确诊复发转移之前。 　　【关键词】 鳞状上皮细胞癌抗原；宫颈上皮内瘤变；宫颈癌 　　 The significance of SCC-Ag in cervical cancer and the association between SCC-Ag and HPV infection 　　Major: Obstertrics and Gynecology Postgraduate: Zhao Xuanyin 　　Supervisor: Professor Wu Xiaoling 　　 [Abstract] Objective: The aim of the papen is to study the significance of SCC-Ag level in the follow-up of CIN and cervical cancer patients. Methods: Peripheral blood samples were obtained from 60 CIN patients, including CIN I,CIN II and CIN III,107 cervical cancer patients and 30 women without cervical lesions. CMIA was carried on to detect the SCC-Ag level in blood serum. Results: There is no significant difference in the SCC-Ag positive incidence between the CIN patients and the control, while the cervical patients and the control were in contrast. In addition, with the degree of cervical lesions increased, SCC-Ag value increased.: As SCC-Ag value increases with the degree of cervical lesions, it may be used as a cervical cancer specific marker and may reflect the cumulative degree and range of lesions to a certain extent. Continuous detection of SCC-Ag value can be used as an assistant measure to evaluate the illness and to predict the recurrence. 　　Key words: Squanous cell carcinoma antigen(SCC-Ag): Cervical intraepithelial neoplasia(CIN); 　　引 言