林木天然物之抗细菌活性.PDFVIP

中華林學季刊 － （ ） － － (Quarterly Journal of Chinese Forestry) 40(4):577 589 2007 577 學術論述 林木天然物之抗細菌活性 1 1 2 3 李文馨 古喬云 張惠婷 張上鎮 （收件日期：民國96 年 8 月 30 日、接受日期：民國96 年 10 月 1 日） 【摘要】細菌是存在於日常生活中的微生物之一，由細菌引起最常見的相關疾病為腸胃 管道方面的疾病，例如霍亂、痢疾等。抗生素的存在雖然能有效地抑制細菌的活性和生 長，然而，大量濫用導致細菌的抗藥性逐年增加，降低了抗生素的功用。近年來，由林 木萃取天然物及其活性之研究漸漸受到重視，許多研究結果顯示，抽出成分具有良好的 抗細菌活性。本文係介紹細菌種類、致病機制與抗藥機制，以及現今實驗室常用的抗細 菌評估方法，並將抽出成分以骨架做一歸類，探討具有抗細菌活性的林木天然物，將 關的文獻做一整體性的整理和討論。期望往後能由林木抽出物中獲得更多具有活性的抽 出成分，開發林木天然物在醫療抗菌方面之用途。 【關鍵詞】抗細菌活性、細菌、林木天然物 ANTIBACTERIAL ACTIVITY OF NATURAL PRODUCTS FROM WOODY PLANTS 1 1 2 3 Wen-Hsin Li Chiao-Yun Ku Hui-Ting Chang Shang-Tzen Chang （Received: August 30, 2007; Accepted: October 1, 2007 ） 【Abstract 】Bacterium is one of the familiar microbes in our life. Intestinal and stomach diseases caused by bacteria are the most common illnesses such as cholera and dysentery. Al- though antibiotics inhibit both activity and growth of bacterium, overuse of antibiotics would lead to antibiotic resistance of bacteria. The incidences of bacteria that resist antibiotics have grown alarmingly, and the efficiency of known antibiotics has decreased. In recent years, there has been a growing interest in studying the natural extracts from woody plants and their bioactivities. Some antibacterial natural products have been found possessing excellent activi- ties. The purpose of this paper is to introduce the types of bacteria, bacterial pathogenesis, an- tibiotic