-黑色素细胞刺激素的抗炎机制.pdfVIP

Chinese Journal of Pathophysiology 2001, 17( 3) :281- 284 ∀ 281 ∀ [ ] 1000- 4718(2001)03- 0281- 04 - * 1 1 1 2 1 陈 波, 胡巢凤 , 王华东, 林 晨, 李楚杰 1 2 ( , , 510632) The anti- inflammatory mechanisms of - melanocyte- stimulating hormone 1 1 1 2 1 CHEN Bo , HU Chao- feng , WAN Hua- dong , LIN Chen ,LI Chu- jie 1 2 ( Dep artment of Pathop hysiology , Dep artment of Microbiology and Immunology , Medical College fo Jinan University , Guangzhou 510632, China [ A Review] - MSH is an endogenous neuropetidethat is effectiveof all categories of expreimental in flammation. Themechanisms underlyingthe anti- inflammatory influenceof - MSH are reviewed in the arti cle. - MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF- B, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti- inflammatory cytokines. - MSH is useful in thetreatment of many patholog ical situations in humans. [] MSH; ; NF- B; [MeSH] MSH; Cytokines; NF- kappa B; Inflammation [] R364.5 [ ] A , , [16] ; , - MSH , - - MSH - MSH 5 (- melanocyte- stimulating hormone, - MSH) (MC- 1R MC- 5R) , , MC- 1R ;MC- 2R ACTH , 1 - MSH ;MC- 3RMC- 4R ; - MSH 13 (Ser- Tyr MC- 5R MC- 1R - Ser- Met- lu- His- Phe- Arg- Trp- ly- Lys- MC- 3RMC- 4RMC- 5R Pro- Val) , C 3Lys- Pro- Val(alpha 2 - MSH - MSH 11- 13