抗生素PPT课件（英文精品） Drug Action in the CellPPT.pptVIP

Predicting Efflux of Antibiotics by AcrAB-TolC Pumps Kelcey Anderson Bioinformatics and Bioengineering Summer Institute Virginia Commonwealth University August 10, 2010 Efflux Pumps Found in Gram-negative bacteria, including E. coli AcrAB-TolC Composed of three parts spanning both the inner and outer cell membranes Responsible for extruding a variety of mainly lipophilic substances Symmons, et al. 2009. PNAS 106:7173-78 AcrB Nature, 2006, 443, 173-179 AcrB has three protomers Protomers exist in either the access, binding, or extrusion state Substrates enter the access state near the inner mem