抗生素PPT课件（英文精品） STUDY OF USE OF ANTIBIOTICS IN THE TREATMENT OF ACUTE SUPPURATIVE OTITIS MEDIA IN A TERTIARY CARE SETUPPPT.ppt

STUDY OF USE OF ANTIBIOTICS IN THE TREATMENT OF ACUTE SUPPURATIVE OTITIS MEDIA IN A TERTIARY CARE SETUP;Abstract Problem Statement: Inappropriate antimicrobial use can lead to emergence of bacterial resistance. In India, the problem of antimicrobial resistance is very high due to factors such as improper prescribing/dosing and easy access to antibiotics over the counter. Management of resistance requires frequent and systematic review of antimicrobial susceptibility testing and rational drug use by way of appropriate guidelines. Objectives: To assess the extent of antibiotic usage in Acute Suppurative Otitis Media (ASOM) at a Government Tertiary Care hospital; to evaluate the antibacterial sensitivity pattern to the antibiotics used in the same; and to prepare guidelines for the use of antibiotics. Design: Prospective, randomized open study. Setting and Population: 1100 bed tertiary care government hospital in urban Bangalore. Study Population: 100 consecutive outpatients of the ENT Department with a diagnosis of ASOM formed the study sample. Intervention: Patient prescription analysis was carried out to assess the type and extent of antibiotics used. Middle ear pus specimens of the patients were taken and processed in the Microbiology department for identification of the organism, followed by sensitivity testing to antibiotics. Outcome Measures: Type of antibiotics used; identification of the organisms; and sensitivity pattern. Results: From the prescription analysis of 100 patients, it was found that Amoxicillin was the drug most widely prescribed, followed by Roxithromycin, Ciprofloxacin, Co-trimoxazole, Doxycycline, Cefuroxime, Azithromycin, Sparfloxacin and Ofloxacin (in descending order). Maximum antibiotic usage was found in the age group of 1-13 yrs. Identification of bacterial isolates was obtained from 86 cultures while the remaining 14 were sterile. The most predominant organism isolated were S. aureus (45 cases) followed by K.pneumoniae (14 cases) an