Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt_β-catenin signaling.pdfVIP

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Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt_β-catenin signaling.pdf

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Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt_β-catenin signaling

Biochemical and Biophysical Research Communications 484 (2017) 586e591 Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: /locate/ybbrc Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt/b-catenin signaling * Lin Rong, Ruixing Zhao, Jinxiu Lu Department of Thoracic Surgery, The Second Peoples Hospital of Liaocheng, Liaocheng, Shandong 252600, China a r t i c l e i n f o a b s t r a c t Article history: Non-small cell lung cancer (NSCLC) is one of the most common and aggressive tumors around the world. Received 21 January 2017 Long-noncoding RNAs (lncRNAs) have been recently shown to play important roles in regulating Accepted 25 January 2017 numerous biological processes including tumor progression. However, the role of lncRNA FOXD2-AS1 in Available online 26 January 2017 NSCLC remains unclear. In this study, we found that lncRNA FOXD2-AS1 is signiﬁcantly up-regulated in NSCLC tissues. Loss- and gain-function assays revealed that FOXD2-AS1 promotes NSCLC cell growth and Keywords: NSCLC tumor progression. Furthermore, we also revealed that FOXD2-AS1 modulates Wnt/b-catenin lncRNA signaling in NSCLC cells. Taken together, we conclude that lncRNA FOXD2-AS1 promotes NSCLC pro- FOXD2-AS1 NSCLC gression though