The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad Ubiquitination Regulatory Factor 2英文文献.pdfVIP

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The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad Ubiquitination Regulatory Factor 2英文文献.pdf

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JBC Papers in Press. Published on September 21, 2010 as Manuscript M110.137471 The latest version is at /cgi/doi/10.1074/jbc.M110.137471 The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad Ubiquitination Regulatory Factor 2 Sewoon Kim and Eek-hoon Jho Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul, Korea, 130-743 Running head: Smurf2 is an E3 ligase for Axin Address correspondence to: Eek-hoon Jho, Ph.D, Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul, 130-743, Korea, Fax: 822-2210- 2888; E-mail: ej70@uos.ac.kr Axin is a negative regulator of Wnt/- Axin plays a crucial role in embryonic catenin signaling via regulating the level of development and tumorigenesis (1). -catenin which is a key effector molecule. Duplication of the embryonic axis in Axin- Therefore, controlling the level of Axin is a /Axin- mouse embryo and blocked embryonic critical step for the regulation of Wnt/- axis formation by ectopic expression of Axin catenin signaling. It has been shown that in Xenopus embryo suggest that Axin is a key ubiquitination-mediated proteasomal regulator of embryonic axis formation via degradation may play a critical role in the regulation of the Wnt pathway, which has regulation of Axin; however, the ubiquitin been shown to play a major role in E3 ligase(s), which attaches ubiquitin to a embryogenesis (2). In this pathway, Axin target protein in combinatio