多发性骨髓瘤继发骨髓纤维化的骨髓病理学特征及与疾病预后的关系.pdfVIP

·1080· 中国实验血液学杂志JournalofExperimentalHematology2017；25(4)：1080—1085 文章编号(ArticleID)：1009—2137(2017)04—1080—06 ·论著· 多发性骨髓瘤继发骨髓纤维化的骨髓病理学特征 及与疾病预后的关系 赵娟，马乐，关键虹4 西安交通大学第一附属医院血液内科，陕西西安710061 摘要 目的：探讨多发性骨髓瘤继发骨髓纤维化的骨髓活检病理特征及其与疾病预后的关系。方法：回顾性分 患者临床资料。观察患者骨髓活检病理学特征，对比分析骨髓涂片及活检增生程度、治疗后纤维化程度的变化，同 时比较继发骨髓纤维化与未发生骨髓纤维化患者之间总死亡率的差异。结果：各期、各分型多发性骨髓瘤均可继 发骨髓纤维化，骨髓纤维化可致骨髓涂片出现假性增生减低，继发骨髓纤维化患者骨髓纤维组织不同程度增生， 发骨髓纤维化时骨髓活检对诊断有重要价值，继发骨髓纤维化患者较未发生纤维化患者总体预后欠佳。 关键词 多发性骨髓瘤；骨髓纤维化；骨髓涂片；骨髓活检；疾病预后 中图分类号R733．3；tt551．3 文献标识码A BoneMarrowin Characteristicsof Pathological MultipleMyeloma Patientswith andTheir SecondaryMyelofibrosis with Prognosis 4 ZHA0 Le。GUAN Juall．MA Jian．H0ng First Xian 71006 University，xfan1，ShaanxiProvince，China DepartmentofHematology，TheAffiliatedHospitalof Jiaotong Author：GUAN Senior +Corresponding Jian—Hong．AssociateTechnologist．E—mail：zjtijmu@163．corn Abstract the characteristicsofbonemarrowin Objective：Toinvestigatepathological multiplemyelomapatients with andtheir with dataof70casesof secondary myelofibrosisrelationshipprognosis．Methods：Clinicalmultiplemye— loma 35 with were from 1SttODecember31 st includingpatientssecondarymyelofibrosisanalyzedretrospectivelyJanuary 2012in of ofour of wellasthe of after DepartmentHematologyhospital，thedegreehyperplasia，aschangesmyelofibros