Concise Review Hitting the Right Spot with Mesenchymal Stromal Cells英文文献.pdfVIP

TRANSLATIONAL AND CLINICAL RESEARCH Concise Review: Hitting the Right Spot with Mesenchymal Stromal Cells JAKUB TOLAR,a KATARINA LE BLANC,b ARMAND KEATING,c BRUCE R. BLAZARa aDivision of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA; bDivision of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden; cCell Therapy Program Princess Margaret Hospital, Toronto, Ontario, Canada Key Words. Mesenchymal stromal cells • Mesenchymal stem cells • Mesenchymal stem cell transplantation • Hematopoietic stem cell transplantation • Graft-versus-host disease • Regenerative medicine ABSTRACT Mesenchymal stromal cells or mesenchymal stem cells recipient. More recently, however, it has become increas- (MSCs) have captured considerable scientific and public ingly clear that even transient MSC engraftment may interest because of their potential to limit physical and exert favorable effects through the secretion of cytokines immune injury, to produce bioactive molecules and to and other paracrine factors, which engage and recruit re- regenerate tissues. MSCs are phenotypically heterogene- cipient cells in productive tissue repair. Thus, an impor- ous and distinct subpopulations within MSC cultures are tant reason to investigate MSCs in mechanistic presumed to contribute to tissue repair and the modula- preclinical models and in clinical trials with well-defined tion of allogeneic immune responses. As the first example end points and controls is to better understand the thera- of efficacy, clinical trials for prevention and treatment of peutic pot