电针天枢、大肠俞治疗功能性腹泻的临床分析word论文.docxVIP

电针天枢、大肠俞治疗功能性腹泻的临床研究学位申请人：田曼导师：黄光英教授中文摘要目的：观察电针刺激天枢、大肠俞治疗功能性腹泻的临床疗效。方法：将50 例符合罗马Ⅲ标准的功能性腹泻患者，按2:1 随机分为电针组和对照组，电针组35 例，对照组15 例。电针组取天枢、大肠俞穴治疗四周，第1、2 周每周连续治疗5次，第3、4 周每周间隔治疗3次；对照组口服盐酸洛哌丁胺，一次2mg，一日3次，连续服用四周。研究周期为10周，即治疗前1周（基线期），治疗期4 周，随访期5 周。患者记录每天排便次数及大便性状。采用焦虑自评量表（SAS）和抑郁自评量表（SDS）分别于入组时、治疗第2 周末和第4 周末对患者进行心理评价。采用健康相关生活质量评分表（SF-36）于入组时和治疗第4 周末对患者进行评价。结果：电针疗法在治疗期和随访期均能明显减少排便次数，改善大便性状，提高正常性状大便的比例，减轻焦虑抑郁状态以及改善SF-36评分，与基线期（第0周）相比差异均有统计学意义（P＜0.05）。但电针组和对照组相比，各项评估指标均无显著性差异（P＞0.05）。结论：电针刺激天枢和大肠俞是治疗功能性腹泻的一种有效办法，能够有效减少排便次数，改善大便性状，提高正常大便比例，患者的焦虑抑郁状态和生活质量均能得到明显改善。与口服盐酸洛哌丁胺相比，疗效无显著差异。关键词：电针；功能性腹泻；天枢；大肠俞ClinicalStudyontheEfficacyofElectroacupunctureatTianshu(ST25)andDachangshu(BL25)forFunctionalDiarrheaCandidate:TianManSupervisor:Prof.HuangGuangyingAbstractObjective: Toobserve the efficacyof electroacupuncture(EA)atTianshu(ST25)and Dachangshu(BL25)inthetreatmentoffunctionaldiarrhea.Methods:Wecollected50patientswhowithfunctionaldiarrheawererandomly assignedtoelectroacupuncturetreatmentgroup(35cases)andcontrolgroup(15 cases),usingtherandomnumbertableina2:1ratio.InEAgroup,patientsweretreatedwithEAatTianshu(ST25)andDachangshu(BL25)bilaterallyfor4weeks, 5timesperweekinthefirstandsecondweek,3timesperweekinthethirdandforth week.Incontrolgroup,thepatientstook2mgloperamidehydrochlorideorallyatatime,3timesaday,continuouslyfor4weeks.Studyperiodlastedfor10weeks, includingone-weekbaseline(beforetreatment),four-weektreatmentperiodandafive-weekfollow-up.Allpatientsshouldrecordstoolfrequencyandcharacterdaily. Self-RatingAnxietyScale(SAS)andSelf-RatingDepressionScale(SDS)wereevaluatedpre-treatment,after2-weektreatmentand4-weektreatment.Theshort-form-36healthsurvey(SF-36)wasevaluatedpre-treatmentandafter4-week treatment.Results:Therewerestatisticallysignificantimprovementsinstoolfrequency,stoolproperties,theSASandSDSscores,thequalityoflifescoresinEAtreatment groupduringtreatmentand follow-upperiod(P＜0.05).ButtherewasnostatisticallysignificantdifferenceinallcriteriabetweenEAtreatmentgroupandthecontrolgr