日本脑炎幻灯片教学讲义.pptVIP

JAPANESE ENCEPHALITIS;Overview;Etiology: The Organism; It has three proteins Envelope protein Core protein Membrane protein;Flaviviruses replication process includes the entry by receptor-mediated endocytosis, uncoating, protein synthesis, viral genome synthesis, assembly, and virus release by budding from plasma membrane or internal membrane. ;History;History;Epidemiology;JE Outbreaks in India;Index case: Nepal, mid-June First case India: July 20th First outbreak alert: August 12th Confirmation JE: August 21th Total death: 1302 Total cases: 5000;Transmission: Susceptible Population;Epidemiologic Feature;DYNAMICS OF JE TRANSMISSION;Pathogenesis;Pathogenesis;Pathogenesis;Pathology;Manifestation;Clinical Manifestations;Four stages;Prodromal Stage; The Acute Encephalitic Stage;The Convalescence Stage;A Sequela Stage;Asymptomatic;Peripheral blood analysis: leucocytosis (10~20)X109/L with neutrophilic＞80% Cerebrospinal fluid (CSF) analysis : Routine: clear, tension elevated, leucocytosis (50~500)X106/L Neutrophils may predominate in early CSF samples but a lymphocytic pleocytosis is typical Biochemistry: protein is moderately elevated glucose and chloride normal level;Laboratory Investigation;Diagnosis;Differential Diagnosis;Prognosis;Treatment;Treatment;Prevention;Vaccination;Inactivated mouse brain vaccine(JE-VAX) Comprising 3 doses: 0.5ml each time and the interval is 1~2 weeks in infancy, boosting 1.0ml in children. Used for endemic or epidemic areas. Recommended for travelers visiting endemic areas for 30 days.