外科-消化性溃疡教材.ppt

Diseases of the Stomach and Duodenum;;PU is caused by an imbalance between secretion of acid and pepsin, and breakdown of mucosal defence. An acid environment and reduced mucosal defences provide ideal circumstances for pepsin to cause mucosal ulceration.;;Over-excitement of vagus nerve--DU Breakdown of mucosal defences--GU Helicobactor Pylori infection---Both;In general terms, the ulcerative process can lead to 4 types of disability: Pain: most common Bleeding Perforation Obstruction;Chief cell-pepsinogen; Men:Women = 3:1 DU : GU = 10 :1 (young)