meta 分析在生物医学领域的应用PPT.pptxVIP

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meta 分析在生物医学领域的应用PPT.pptx

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meta 分析在生物医学领域的应用PPT

Meta-Analysis and Bayesian Meta-Analysis of Phase III Randomized Controlled Trials---Bortezomib-Based Versus Non-bortezomib-Based Post-Transplantation Treatment in Multiple Myeloma Patients刘小平 MS、邵亮 MD、刘尚勤MD武汉大学中南医院Colin K. He, PhD., MSMultiple myeloma (MM)Multiple myeloma is the malignant counterpart of long-lived plasma cells with a strong tropism for bone and bone marrow. Epidemiology of MMMultiple myeloma is the second most frequent haematological malignancy with an age-adjusted incidence of six per 100 000 per year in the USA and Europe.The incidence of multiple myeloma is two to three times higher in African Americans, making it the most common haematological malignancy in this ethnic groupClinical PresentationsBone pain; lytic lesions on imaging; unexplained hypercalcemia; acute renal failuresystemic signs : fatigue, weakness, and weight loss; or increased total serum protein levelentOverall survival after diagnosis in patients with multiple myelomaFlow diagram of study selection Funnel plots of overall response rate before and after the “trim and filled” method was appliedMeta-analysis of overall response rate after one hypothetical study was added to the integrated analysis INSTALL RCMDRPLUGIN.EZRhttp://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmedEN.htmlhttp://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmedEN.htmlManuelMANUELFixed ModelDon’t check Conduct random…Meta-analysis of complete response or near complete response---Forrest and Accumulated Forest PlotsR Code for Accumulated ForestR Code (Case Sensitivity):resCum- metacum(res, pooled=fixed)forest(resCum)Relative Risk/Risk DifferenceProgression-free survival (PFS) ---Forest and Accumulation Forest PlotsOverall survival (OS)Bayesian Meta-AnalysisOverall survival (OS)Log Scale Estimate Var 2.5% 50% 97.5%HR mu -00-0-0.2529008 0.3391747tausq 00 0 0.0000000 0.0000000Q 11 0 0