NHS临床指南 IPT and ICF Guidelines Update.ppt

IPT and ICF Guidelines Update;TB related questions;Havlir, Getahun et al. 2008 JAMA 300(4):423-430;;WHO/UNAIDS 1998 IPT Policy;WHO Guidelines for National TB Programmes on the management of children;WHO HIV/AIDS Department Priority Interventions (IAS Mexico 2008);Implementation progress;;Guidelines Review Committee rationale;1. Scoping the document: reasons for choosing the topic, problems with existing guidelines, variations and gaps, ;Ideal recommendations Screening algorithm for IPT and further TB evaluation Recommendations regarding diagnostic methods for ruling out TB Preferred regimen for adults and children Answer questions regarding duration, toxicity, cost, and resistance Populations being considered HIV+ adults, adolescents and children HIV+ pregnant women Relevant outcomes Mortality Disease progression (morbidity) Severe or regimen limiting adverse events Adherence and retention on IPT Durability of IPT regimen effect Cost effectiveness ;Expected functions of the guideline group;PICOT framework;Judgments about the strength of a recommendation –criteria to consider for WHO;Population group: PLWHA children;Considering cost ;End of the day…Recommendation(s);Other WHO guidelines;;Thank you