新型植入式胃电刺激器的刺激效果及组织相容性-中国医疗器械杂志.PDF

Chinese Journal of Medical Instrumentation 2011 年35 卷第6 期 研 究 与 论 著 文章编号 1671-7104(2011)06-04 18-04 ： 新型植入式胃电刺激器的刺激效果 及组织相容性动物实验研究 李艳梅1,2 2 3 2 2 2 2 3 【作 者】 ，姚树坤 ，麦宋平 ，姚力 ，陈少轩 ，张伟硕 ，郭文娟 ，张春 1 北京协和医学院中国医学科学院，北京，100730 2 中日友好医院消化内科，北京，100029 3 清华大学微电子学研究所，北京，100084 【摘 要】介绍一种新型胃电刺激器，通过动物实验，观察植入体内后的刺激效果，并观察植入部位的病理反应，探讨胃电刺激器的 安全性和有效性，以及所用材料的组织相容性。结果表明，该仪器安全，能够减少动物的摄食量，所用材料组织相容性 良好。 【关 键 词】 胃电刺激器；植入；组织相容性 【中图分类号】R318.6 【文献标志码】A doi:10.3969/j .issn.1671-7104.2011.06.006 Experimental Study on the Stimulating Effect and the Tissue Compatibility of a New Type of Implanted Gastric Electrical Stimulator 【Writers 】 1,2 2 3 2 2 2 2 3 Li Yanmei , Yao Shukun , Mai Songping , Yao Li , Chen Shaoxuan , Zhang Weishuo , Guo Wenj uan , Zhang Chun 1 Peking Union Medical College Chinese Academy of Medical Sciences, Beij ing 100730 2 Department of Gastroenterology ，China-Japan Friendship Hospital, Beij ing 100029 3 Institute of Microelectronics, Tsinghua University, Beij ing 100084 A new type of gastric electrical stimulator(GES) was 【Abstract 】introduced. After the stimulator was implanted in beagle dogs, its stimulating effects and the pathological changes at the implant site were observed to study the safety and efficacy of stimulator as well as the tissue compatibility of the materials used. The results showed that, this type of stimulator was safe and capable of inhibiting food intake of the dogs, and that the materials used had good tissue compatibility. 【 】 Key words gastric electrical stimulator, implant, tissue c