[工学]生物信息学课件-中科院—6-贝叶斯网络.ppt

Introduction to Systems Biology Why systems biology What is systems biology What does systems biology do The history of systems biology Tools for systems biology High-throughput experimental technologies and computational resources promote the birth of “systems biology” Genome sequence Microarray Protein-protein interaction High-throughput experimental technologies and computational resources promote the birth of “systems biology” How to intergrate these data together to explaing the control theory of biological systems? What Is Systems Biology Systems biology is basically the approaches to study complex biological systems by looking at all the elements in the system , in terms of perturbations and model organisms, rather than looking at things one at a time. First described by Leroy Hood in 1999 What Is Systems Biology Definition of Systems biology There have been a number of different definitions almost with all terms of biology and names of many subjects An approach of biology in which seeks to explain biological phenomenon not on a gene-by-gene basis, but through the interaction of all the cellular and biochemical components in a cell or an organism. General definition What does Systems Biology Do? A. System structures: network of gene interactions and biochemical pathways B. System dynamics: how a system behaves over time under various conditions C. The control method : mechanisms that systematically control the state of the system D. The design method: strategies to modify and construct biological systems Systems biology focuses on the study of: The History of Systems Biology The system control concept could be dated back to 1948 NORBERT WIENER (1894 – 1964) the founding father of cybernetics Cybernetics – Control and Communication in the Animal and the Machine. In the 1960s, systems theory and biology enjoyed ``considerable interest among eminent scientists, mathematicians and engineers The History of Systems Bi