课件6-3-Polymeric biomaterials3.pptVIP

Chapter 6 Functional Polymers  6.7 Polymeric Biomaterials Content Introduction Brief History General Application Common Polymeric Biomaterials Conclusion 1. Introduction What are Biomaterials? natural or man-made origin that are used to direct, supplement, or replace the function of living tissues of the human body any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function 1. Introduction Understanding Biomaterials 1. Introduction Biomaterial Science Key: Control/understand interface reaction 1. Introduction Applied Biomaterial Science 1. Introduction What Biomaterials Differ with Other Materials? Biofunctionality Biocompatibility Biofunctionality a natural function that a biomaterial can perform Biocompatiblity Definition the ability of a materials to perform with an appropriate host response, in a specific application. A developing term Bioinert: no interaction with biological system Bioactive: positive interaction with biological system Surface and structural one Surface: chemical, and physical (including surface morphology) suitability of an implant surface to the host tissue. Structure: optimal adaptation to the mechanical behavior of the host tissues. 1. Introduction Body Environment that Biomaterials Survive pH range: 1~9 Average stress on bone: 4 MPa Peak stress on tendons and ligaments : 40~80 MPa Mean load on hip joint: 3 times BW; when jumping 10 times BW Stress cycle per y: finger or hip joint 1×106 cycles ; heart 0.5×107-4×107 cycles 1. Introduction Market of Biomaterials 2700 biomedical device, 2500 separate diagnostic products , 39,000 different pharmaceutical preparations. world market for all medical devices