微小RNA与心肌缺血.pdfVIP

2 1 1 23 1 J M ed Postgra, Vol. 23, No. 1 , October, 2 1 1 85 RNA 方 际, 袁文俊, 林 丽 [ ] RNA(M icroRNA, m iRNA) RNA, RNA(m essenger RNA, mRNA) 3( 3untranslated region, 3UTR), mRNA ( ), 1 m iRNA mRNA , m iRNA , m iRNA , m iRNA , , [ ] RNA; ; ; ; [ ] Q522 [ ] A [ ] 1 88199( 2 1 ) 1 1 85 5 M icroRNA and m yocardial ischem ia FANG Jireviewing, YUAN W enjun, LIN L i checking (Departm ent of Physiology, SecondM ilitaryM edical University, Shanghai 2 433, China) [ A bstract ] M icroRNA (m iRNA ) are a class of endogenous sm all RNA involved in posttranscriptional regu lation. Based on the basepairing principle, m iRNA bind to comp lem entary sequences that are usually located in the 3untranslated region ( 3UTR) of target mRNA, then triggermRNA cleavage and/ or translational repression. Bioinform ational analyses pred icted that one m iRNA can target hundreds of mRNA, indicating the m ultiplicity of m iRNA function. Recen t research dem onstrated a close correlation between m iRNA and card iovascular diseases. Changes ofm iRNA expression were show ed to play p ivotal roles in the pathologic processes inclu d ing m yocard ial ischem ia, ischem ic arrhythm ia and postischem ic vascular genesis. The involvem ent of m iRNA in ischem ic heart dis easew as summ arized in th is review. [ K ey w ords ] M icroRNA; M yocard ial ischem ia; V entricu lar remodeling; C ard iac arrhythm ias; Pathologic neovascularization 在细胞增殖分化免疫调节凋亡死亡等生理病理 0 [ 3- 6] 过程中, m iRNA 的调节作用不容忽视 , 某些 [ 7] m iRNA 是 一类高度保守长约 19~ 25 个核苷酸 m iRNA缺乏可导致组织器官的发育障