药物合成反应作业精品.pptVIP

Total Synthesis of Amphirionin 4 -Michael Holmes, Daniel Kwon, Matthew Taron, and Robert Britton 演讲小组成员：陈人豪、王兴瑞、黄渊 主讲人：陈人豪 1 CONTENT 1.合成化合物的结构与活性The structure and activity of synthetic compounds 2.逆合成设计思路Inverse synthetic design thinking 3.中间体的合成synthesis of intermediate 4.Amphirionin-4”s nmr data 5.有关反应的反应条件与机理（附） The reaction conditions and related mechanism 2 Amphidinium species of marine dinoflagellates Amphidinium species of marine dinoflagellates have proven to be a rich source of structurally diverse polyketides,1 many of which are characterized by cyclic ethers of various ring sizes