【医学课件大全】1型糖尿病候选基因的筛选 (41p)课件.pptVIP

* Figure 2: Venn diagram showing numbers of significantly dysregulated genes shared by the three tissues (PLN, SPL and PBC) from 10 days to 4 weeks (A; early stage) and from 8 to 20 weeks of age (B; late stage). 早期 晚期 * Figure 5: Hierarchic clustering analysis for all milestone gene expression profiles indicates the five distinct clusters in PLN while two simple clusters were detected in both PBC and SPL. * * 基因表达变化 疾病相关基因功能的获得或丢失的原因： 单核苷酸多态性（SNP）或突变 非典型变构体或转录水平调控－假说 （标志？） PLN中“N”型基因？？ * N pattern in PLN * PLN中“N”型基因 胰淋巴结是一个很重要的外周免疫器官，胰岛b细胞抗原需要特异的被转运到PLN，然后才被提呈给MHC类分子。 最近的研究还发现，PLN的基