[]中山大学生化课件.pptVIP

liguofu Fat soluble Vitamins vitamins A,D,E,K Long chain polyunsaturates hydrocarbons attached to 1 or 2 benzene rings Aspirin and Ibuprofen belong to Non-Steroidal Anti-Inflammatory Drugs ,NSAIDs . Ibuprofen (布洛芬) inhibits the same step, probably by mimicking the structure of the substrate or an intermediate in the reaction. Aspirin inhibits the cyclooxgenase activity of COX by acetylating an essential Ser residue on the enzyme. Derivates of sterols; Play important roles in gene expression; Sex hormones and hormones from adrenal cortex; Prednisolone and prednisone are steroid drug with potent antiinflammatory activities. Steroid hormones carry messages between tissues 睾丸酮 雌二醇 皮质(甾)醇,氢化可的松 醛固酮 脱氢皮质(甾)醇 强的松 Vitamin A (retinol) stored in liver precursor:carotene deficiency: night blindness Vitamin D formed from precursor in skin by UV regulates Ca deposition deficiency: rickets Active VitD3 Vit D3 is formed in skin 1,25-dihydroxy VitD3 is biological active; It regulates gene expression, e.g. turning on the synthesis of an intestinal Ca 2+ binding protein. Vitamins E and K and Lipid Quinones are oxidation-reduction cofactors Vit E: biological antioxidants; Vit K: undergoes a cycle of oxidation and reduction; during the formation of active prothrombin; Warfarin: synthetic compound that inhibits the formation of active prothrombin; Ubiquinone (coenzyme Q) and plastoquitone: isoprenoids that functionas lipophilic electron carriers in the oxidation-reduction reactionsthat drive ATP synthesis in mitochondria and chloroplasts, respectively. Active sugar precursors §9 Lipids §9.1 Storage lipids §9.2 Structural lipids in membranes §9.3 Lipids as signals, cofactors, and pigments §9.4 Separation and analysis of lipids Separation and Analysis of Lipids Lipid extraction requires organic solvents Adsorption chromatography separates lipid of different polarity Gas-lipid chromatography resolves mixture of volatile lipid derivates