肺能生血教学教材演示幻灯片.pptxVIP

文献阅读分享——周旋一Title目的Background目的二ABSTRACTMethod 方法方法Result结果结果结论Conclusion结论TitleThe lung is a site of platelet biogenesis anda reservoir for haematopoietic progenitorsBackground Platelets are critical for haemostasis, thrombosis, and inflammatory responses, but the events that lead to mature platelet production remain incompletely understood. The bone marrow has been proposed to be a major site of platelet production, although there is indirect evidence that the lungs might also contribute to platelet biogenesis。Method and Materials By directly imaging the lung microcirculation in mice。 Result 1we show that a large number of megakaryocytes circulate through the lungs, where they dynamically release platelets. Megakaryocytes that release platelets in the lungs originate from extrapulmonary sites such as the bone marrow; we observed large megakaryocytes migrating out of the bone marrow space. The contribution of the lungs to platelet biogenesis is substantial, accounting for approximately 50% of total platelet production or 10 million platelets per hour。Result 2Furthermore, we identified populations of mature and immature megakaryocytes along with haematopoieticprogenitors in the extravascular spaces of the lungs. Under conditions of thrombocytopenia and relative stem cell deficiency in the bone marrow, these progenitors can migrate out of the lungs, repopulate the bone marrow, completely reconstitute blood platelet counts, and contribute to multiple haematopoietic lineagesConclusionThese results identify the lungs as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.Analysis 1Blood leaving the lungs contains more platelets and fewer megakaryocytes than blood entering the lungs。To investigate the origin of the intravascular megakaryocytes and proplatelets in the lungs，we……Analysis 2To further characterize lung megakaryocytes, we……To test the function of extravascular megakaryocytes in the lungs, We next tested wheth