EGF Increases TRPM Activity and Surface Expression增加活性和表面表达.pdfVIP

BASIC RESEARCH EGF Increases TRPM6 Activity and Surface Expression Ste´ phanie Thebault, R. Todd Alexander, Wouter M. Tiel Groenestege, Joost G. Hoenderop, and Rene´ J. Bindels Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands ABSTRACT Recent identification of a mutation in the EGF gene that causes isolated recessive hypomagnesemia led to the finding that EGF increases the activity of the epithelial magnesium (Mg2) channel transient receptor potential M6 (TRPM6). To