Low magnitude high frequency vibration accelerates callus…低幅度的高频振动加速愈伤组织.pdfVIP

Low-Magnitude High-Frequency Vibration Accelerates Callus Formation, Mineralization, and Fracture Healing in Rats Kwok Sui Leung, Hong Fei Shi, Wing Hoi Cheung, Ling Qin, Wai Kin Ng, Kam Fai Tam, Ning Tang Department of Orthopaedics and Traumatology, 5/F, Clinical Science Building, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People’s Republic of China Received 28 August 2007; accepted 8 July 2008 Published online 15 October 2008 in Wiley InterScience (). DOI 10.1002/jor.20753 ABSTRACT: Fracture healing is a biological regenerative process that follows a well-orchestrated sequence. Most healing is uneventful and enhancement of normal fracture healing is not commonly done, although it is clinically important in the recovery and regain of functions after fracture. This study investigated the osteogenic effect of low-magnitude high-frequency vibration (LMHFV, 35 Hz, 0.3g ) on the enhancement of fracture healing in rats with closed femoral shaft fracture by comparing with sham-treated control. Assessments with plain radiography, micro-CT as well as histomorphometry showed that the amount of callus was significantly larger (p ¼ 0.001 for callus area, 2 weeks posttreatment); the remodeling of the callus into mature bone was significantly faster (p ¼ 0.039, 4 weeks posttreatment) in the treatment group. The mechanical strength of the healed fracture in the treatment group at 4 weeks was significantly greater (p 0.001). The results showed the acceleration of callus formation, mineralization, and fracture healing in the treatment group. It is concluded that LMHFV enhances healing in the closed femoral shaft fracture in rats. The potential clinical advantages shall be confirmed in the subsequent clinical trials. 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:458–465, 2009 Keywords: low-magnitude high-frequency vibration; fracture healing; callus; femur;