Monitoring Human Immunodeficiency Type Infected Patients…监测人类免疫缺陷型感染患者.pdfVIP

JOURNAL OF CLINICAL MICROBIOLOGY, May 1989, p. 843-848 Vol. 27, No. 5 0095-1137/89/050843-06$02.0O/O Copyright C 1989, American Society for Microbiology Monitoring Human Immunodeficiency Virus Type 1-Infected Patients by Ratio of Antibodies to gp4l and p24 G. SCHMIDT,* K. AMIRAIAN, H. FREY,2 J. WETHERS, R. W. STEVENS, AND D. S. BERNS Wadsworth Center for Laboratories and Research, New York State Department ofHealth, Albany, New York 12201, and St. Johns Riverside Hospital, Yonkers, New York 107012 Received 24 October 1988/Accepted 23 January 1989 Antibody responses of 85 patients to human immunodeficiency virus type 1 antigens were quantitated by densitometric analysis of Western blot (immunoblot) assays. All patients had been classified into the following three clinical categories: asymptomatic (ASY), acquired immunodeficiency syndrome (AIDS)-related coniplex (ARC), or AIDS. Fifty of the patients were monitored for 6 to 29 months. The gp4l/p24 antibody ratio was examined in three studies. In the first study, initial specimens from each patient were analyzed. The mean gp4l/p24 antibody ratios were 1.5 (ASY), 3.2 (ARC), and 5.4 (AIDS). Of ASY patients, 79% had antibody ratios of 2.0. In contrast, 72% of patients with AIDS had ratios of .2.0. In the second study, serially obtained specimens from ASY, ARC, and AIDS patients were analyzed. These patients were further grouped according to progression of their clinical condition. Of ASY patients whose clinical condition progressed to ARC, 80% consistently had ratios of .2.0. OfARC patients whose clinical condition progressed to AIDS, 71 % consistently had ratios of .2.0. Of AIDS patients who died during the stu