Monitoring of Specific Antibodies to Human Immunodeficiency…监测针对人类免疫缺陷的特异性抗体.pdfVIP

From by guest on February 24, 2016. For personal use only. Monitoring of Specific Antibodies to Human Immunodeficiency Virus Structural Proteins: Clinical Significance By Jean-Pierre Allain, Yves Laurian, Mark H. Einstein, Brian P. Braun, Stephen R. Delaney, John E.Stephens, Cynthia K. Daluga, Stephen J. Dahlen, and Kevin M. Knigge Levelsof antibodiesto six majorstructural proteins of human irrespective of their clinical condition for 4 to 6 years after immunodeficiencyvirus type 1 (gp120, gp41, p66, p31, p24, seroconversion. In contrast, immune response to p66 and and p17) were assessed in serial samples from 22 persons p17 was significantly lower in symptomatic patients. Over with severe hemophilia (16 asymptomatic and 6 who devel- time, the levels of these two antibodies, as well as anti-p24, oped acquired immunodeficiency syndrome [AIDS] or AIDS- decreased and tended to become undetectable. Abnormal related complex) with an automated dot blot assay using immune response and low levels of antibody to p66 and p17 purified recombinant antigens. High and sustained levels of are early indications of rapid clinical progression. antibody to gp120, gp41, and p31 were found in all patients 01991by TheAmerican Society of Hematology. UMAN IMMUNODEFICIENCY virus (HIV) infec- infection, some clinical AIDS cases have been observed H tion is serologically characterized by the develop- where no antibody to HIV was detectable by either enzyme ment of antibodies to structural and, in most cases, to immunoassay or Western blot.” In addition, the presence of regulatory g